CBFA2T3 and ZNF652

Number of citations of the paper that reports this interaction (PubMedID 16966434)
0

Data Source:
HPRD (in vivo)

		CBFA2T3	ZNF652
Description		CBFA2/RUNX1 partner transcriptional co-repressor 3	zinc finger protein 652
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Response To Hypoxia DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Differentiation Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Aerobic Respiration	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hair color ( 26926045) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Social autistic-like traits ( 24133439) Vitiligo ( 27723757)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 34103634 29273806 32296059 31959851 30929738 31619474 31361310) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Atopic dermatitis ( 23727859) Blood pressure ( 21909110) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cancer ( 29299148) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618452 27618447 28739976 19430483) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Egg allergy (maternal genetic effects) ( 29489655) Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Height ( 20881960) Intraocular pressure ( 29785010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732 21602798 34012061) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22829776) Systolic blood pressure ( 27841878 27618452) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		23 interacting genes: ARHGEF6 CBFA2T2 CHRM4 DRC4 EPM2AIP1 GATAD2A GMEB2 HDAC1 HDAC3 MATN2 PIN1 PRKAR2A RTN4IP1 RUNX1 RUNX1T1 SEC24A TCF3 VPS37C ZBTB33 ZBTB38 ZBTB4 ZBTB47 ZNF652	4 interacting genes: CBFA2T2 CBFA2T3 RUNX1T1 TRIM14
Entrez ID		863	22834
HPRD ID		04847	18362
Ensembl ID		ENSG00000129993	ENSG00000198740
Uniprot IDs		O75081	A8K9F2 D6RF85 Q9Y2D9
PDB IDs		9DE2
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Protein Lysine Delactylase Activity Methyl-CpG Binding Negative Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Protein Deacetylation Protein Lysine Deacetylase Activity Transcription Corepressor Activity Nucleoplasm NuRD Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Deacylation NF-kappaB Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Telomere Tethering At Nuclear Periphery Cis-trans Isomerase Activity Positive Regulation Of Ferroptosis Methyl-CpNpG Binding Regulation Of Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Cell Fate Commitment	Transcription Corepressor Activity DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Glycosylated Region Protein Binding Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Negative Regulation Of T Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Matrix Metallopeptidase Secretion Intestinal Epithelial Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of Lymphocyte Migration Negative Regulation Of Macrophage Migration Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Macrophage Activation Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Viral Transcription Regulation Of Viral Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of ATP Metabolic Process Metal Ion Binding Granulocyte Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Macrophage Activation Protein K48-linked Deubiquitination
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