CBFA2T3 and ZBTB38

Number of citations of the paper that reports this interaction (PubMedID 23251453)
47

Data Source:
BioGRID (two hybrid)

		CBFA2T3	ZBTB38
Description		CBFA2/RUNX1 partner transcriptional co-repressor 3	zinc finger and BTB domain containing 38
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane	Nucleus Nucleoplasm Chromosome Blood Microparticle
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Hypoxia DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Differentiation Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Aerobic Respiration	Regulation Of DNA Replication Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hair color ( 26926045) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Social autistic-like traits ( 24133439) Vitiligo ( 27723757)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Asthma ( 32296059 30929738) Asthma (childhood onset) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Diastolic blood pressure ( 27618447) Estimated glomerular filtration rate ( 31152163) Fasting glucose ( 34059833) Hair color ( 29662168) Heel bone mineral density ( 30598549) Height ( 31562340 33713608 18193045 28270201 34270706 28552196 18391950 18391951 25282103 23563607 25429064 18391952 21998595 20881960 19343178 20189936 19893584 19396169) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Infant length ( 25281659) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602 31604244) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Physiological traits ( 31902109) Prion diseases ( 22210626) Prostate cancer ( 21743467) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Pulmonary function in asthmatics ( 25221879) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Serum total protein levels ( 29403010) Soluble receptor for advanced glycation end-product levels ( 26915486) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27618447) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 25673412) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 28552196 25673412 34021172) Weight ( 28552196)
Interacting Genes		23 interacting genes: ARHGEF6 CBFA2T2 CHRM4 DRC4 EPM2AIP1 GATAD2A GMEB2 HDAC1 HDAC3 MATN2 PIN1 PRKAR2A RTN4IP1 RUNX1 RUNX1T1 SEC24A TCF3 VPS37C ZBTB33 ZBTB38 ZBTB4 ZBTB47 ZNF652	19 interacting genes: CBFA2T3 CCDC136 EHMT2 ERCC6 FSD2 KCNJ6 KRT40 KRTAP10-7 KRTAP10-9 LZTS2 MTUS2 MYBPH PDE4DIP RALBP1 RBBP6 RSPH1 TRAPPC2 TRIM41 TSGA10
Entrez ID		863	253461
HPRD ID		04847	10985
Ensembl ID		ENSG00000129993	ENSG00000177311
Uniprot IDs		O75081	Q8NAP3 Q9H6F0
PDB IDs		9DE2	6E93 6E94
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Protein Lysine Delactylase Activity Methyl-CpG Binding Negative Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Protein Deacetylation Protein Lysine Deacetylase Activity Transcription Corepressor Activity Nucleoplasm NuRD Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Deacylation NF-kappaB Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Telomere Tethering At Nuclear Periphery Cis-trans Isomerase Activity Positive Regulation Of Ferroptosis Methyl-CpNpG Binding Regulation Of Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Cell Fate Commitment	Cytoskeleton Keratin Filament
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