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GRAP2 and BLNK
Number of citations of the paper that reports this interaction (PubMedID
12773374
)
77
Data Source:
BioGRID
(unspecified method, affinity chromatography technology)
HPRD
(in vivo, in vitro)
GRAP2
BLNK
Description
GRB2 related adaptor protein 2
B cell linker
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Lipid Binding
Enzyme Binding
Protein Kinase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Phospholipase Binding
Molecular Condensate Scaffold Activity
Protein Tyrosine Kinase Binding
Biological Process
Signal Transduction
Ras Protein Signal Transduction
Cell-cell Signaling
Regulation Of MAPK Cascade
Inflammatory Response
Humoral Immune Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
Intracellular Signal Transduction
B Cell Activation
B Cell Receptor Signaling Pathway
Pathways
Signaling by SCF-KIT
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Co-stimulation by CD28
FLT3 Signaling
Signaling by CSF1 (M-CSF) in myeloid cells
Regulation of signaling by CBL
Potential therapeutics for SARS
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Body mass index (
26426971
)
Systemic lupus erythematosus (
28714469
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
78 interacting genes:
AR
BAG4
BEND5
BLNK
CBL
CBLB
CBY2
CCHCR1
CCNDBP1
CD28
COG6
CSF1R
DNM2
DVL2
EGFR
ERBB2
ERBB3
ERBB4
ETV5
FASLG
GAB1
GAB2
GAB3
GAREM1
GATA1
GFAP
GOLGA2
GRB2
HNRNPK
IHO1
IKZF3
KHDRBS1
KHDRBS2
KIT
KPRP
KRT13
KRTAP1-3
KRTAP4-11
KRTAP4-12
LAT
LATS2
LAX1
LCP2
LNX1
LNX2
MAGED1
MAP4K1
MKRN3
MOS
MTUS2
PBLD
PNMA1
PRKAA2
PRPH2
PRR35
RACK1
RAVER1
RBPMS
RIN3
RINT1
SH2D4A
SHB
SHC1
SOS2
SPRY2
SSX2IP
STAMBP
TFIP11
TLE5
TRAF1
TSNAXIP1
USP8
WWP2
YWHAE
ZBTB7B
ZNF250
ZNF319
ZNF526
25 interacting genes:
AR
BTK
CBL
CBLB
CD72
CD79A
CMTM3
CRKL
EGFR
ERBB2
ERBB3
GAB1
GRAP2
GRB2
ITK
KIT
LCP2
MAP4K1
NCK1
PLCG1
PLCG2
PTPN6
SH3KBP1
SYK
VAV1
Entrez ID
9402
29760
HPRD ID
05156
05153
Ensembl ID
ENSG00000100351
ENSG00000095585
Uniprot IDs
B7Z8E3
B7Z8F8
O75791
Q6FI14
Q2MD54
Q2MD59
Q8WV28
PDB IDs
5GJH
6YLU
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
ERBB Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signaling Adaptor Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
SH2 Domain Binding
Antigen Receptor-mediated Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Binding
Positive Regulation Of Protein Modification Process
Identical Protein Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Signal Transduction
Negative Regulation Of Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Modification Process
Lymphocyte Activation
Intracellular Signaling Cassette
Negative Regulation Of Apoptotic Process
Leukocyte Activation
Positive Regulation Of Phosphate Metabolic Process
Phosphotyrosine Residue Binding
Positive Regulation Of Phosphorylation
Cellular Response To Epidermal Growth Factor Stimulus
Immune Response-regulating Signaling Pathway
ERBB2 Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Response To Epidermal Growth Factor
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Immune Response-regulating Signaling Pathway
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune Response
Intracellular Signal Transduction
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Leukocyte Activation
Lymphocyte Activation
B Cell Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Activation
Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cell-cell Junction
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Fc Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
T Cell Activation
Immune System Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Protein Tyrosine Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Leukocyte Proliferation
ERBB Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Regulation Of Lymphocyte Activation
Receptor Tyrosine Kinase Binding
Cell Population Proliferation
Plasma Membrane
Negative Regulation Of Immune System Process
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