GRAP2 and ZBTB7B

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRAP2	ZBTB7B
Description		GRB2 related adaptor protein 2	zinc finger and BTB domain containing 7B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Nucleus Nucleoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Regulation Of MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Co-stimulation by CD28 FLT3 Signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	A body shape index ( 34021172) Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		78 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526	27 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B
Entrez ID		9402	51043
HPRD ID		05156	09625
Ensembl ID		ENSG00000100351	ENSG00000160685
Uniprot IDs		B7Z8E3 B7Z8F8 O75791 Q6FI14	O15156
PDB IDs		5GJH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade SH2 Domain Binding Antigen Receptor-mediated Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Binding Positive Regulation Of Protein Modification Process Identical Protein Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Modification Process Lymphocyte Activation Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Immune Response-regulating Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor	Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of RNA Metabolic Process Phosphotyrosine Residue Binding Negative Regulation Of RNA Biosynthetic Process Type 2 Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Activation SH3 Domain Binding Small GTPase-mediated Signal Transduction DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleoplasm DNA Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lymphocyte Activation Positive Regulation Of Cell Adhesion Regulation Of DNA Recombination Regulation Of Cell-cell Adhesion Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Vesicle Membrane Non-canonical NF-kappaB Signal Transduction Cis-trans Isomerase Activity
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