GRAP2 and GAB3

Number of citations of the paper that reports this interaction (PubMedID 12773374)
77

Data Source:
HPRD (in vitro)

		GRAP2	GAB3
Description		GRB2 related adaptor protein 2	GRB2 associated binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Signaling Adaptor Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Regulation Of MAPK Cascade	Signal Transduction Macrophage Differentiation
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Co-stimulation by CD28 FLT3 Signaling Signaling by CSF1 (M-CSF) in myeloid cells	Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Glycated hemoglobin levels ( 34059833) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 28453575) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		78 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526	8 interacting genes: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC
Entrez ID		9402	139716
HPRD ID		05156	06571
Ensembl ID		ENSG00000100351	ENSG00000160219
Uniprot IDs		B7Z8E3 B7Z8F8 O75791 Q6FI14	Q8WWW8
PDB IDs		5GJH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade SH2 Domain Binding Antigen Receptor-mediated Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Binding Positive Regulation Of Protein Modification Process Identical Protein Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Modification Process Lymphocyte Activation Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Immune Response-regulating Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor	T Cell Costimulation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Activation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of Cell Adhesion Immune Effector Process Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Regulation Of Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Defense Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Immune System Process Cell Motility Regulation Of Lymphocyte Activation Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Localization Negative Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling
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