GRAP2 and LCP2

Number of citations of the paper that reports this interaction (PMID 10021361)
68

Data Source:
HPRD (in vivo, in vitro)

		GRAP2	LCP2
Gene Name		GRB2-related adaptor protein 2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol	Cytosol Cell-cell Junction
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Platelet Activation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Mast Cell Activation Cytokine Secretion T Cell Receptor Signaling Pathway
Pathways		DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System	DAP12 interactions Generation of second messenger molecules FCERI mediated MAPK activation DAP12 signaling TCR signaling GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B	39 interactors: APP BLNK CBL CD22 CLNK FXR2 FYB FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LYN MAP4K1 NCK1 NCK2 PAG1 PIK3R1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAZ ZAP70
Entrez ID		9402	3937
HPRD ID		05156	03362
Ensembl ID		ENSG00000100351
Uniprot IDs		B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation	Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Activation Immune System Process Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Innate Immune Response Defense Response Fc-epsilon Receptor Signaling Pathway Platelet Activation Regulation Of Signal Transduction Leukocyte Activation Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Signaling Blood Coagulation Signal Transduction Hemostasis Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Signaling Leukocyte Migration Lymphocyte Activation Cell Communication Positive Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Body Fluid Levels Positive Regulation Of Cell Adhesion Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation
Tagcloud ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined	aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?