GRAP2 and GAREM1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)

		GRAP2	GAREM1
Description		GRB2 related adaptor protein 2	GRB2 associated regulator of MAPK1 subtype 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Protein Binding Proline-rich Region Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Regulation Of MAPK Cascade	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Multicellular Organism Growth Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Co-stimulation by CD28 FLT3 Signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Breast cancer ( 29059683) Left ventricular internal dimension in diastole ( 29403010) Left ventricular internal dimension in systole ( 29403010)
Interacting Genes		78 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526	5 interacting genes: CFTR CRK CRKL GRAP2 NCK2
Entrez ID		9402	64762
HPRD ID		05156	12685
Ensembl ID		ENSG00000100351	ENSG00000141441
Uniprot IDs		B7Z8E3 B7Z8F8 O75791 Q6FI14	Q9H706
PDB IDs		5GJH	2DKZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade SH2 Domain Binding Antigen Receptor-mediated Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Binding Positive Regulation Of Protein Modification Process Identical Protein Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Modification Process Lymphocyte Activation Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Immune Response-regulating Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor	Phosphotyrosine Residue Binding Helper T Cell Diapedesis Cerebellar Neuron Development Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Postsynaptic Specialization Organization Signaling Receptor Complex Adaptor Activity Regulation Of Rac Protein Signal Transduction T Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Dendrite Development Central Nervous System Neuron Development Regulation Of T Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Ephrin Receptor Signaling Pathway Lymphocyte Migration Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Localization Regulation Of Lymphocyte Migration Hippocampus Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scaffold Protein Binding Response To Transforming Growth Factor Beta Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Ras Protein Signal Transduction Positive Regulation Of Cell Adhesion Cerebral Cortex Development Regulation Of Cellular Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Protein Localization To Membrane Establishment Of Cell Polarity Regulation Of Dendrite Development Regulation Of Cell Communication Regulation Of Signaling Mononuclear Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Anion Channel Activity Positive Regulation Of Signaling
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