GRAP2 and SOS2

Number of citations of the paper that reports this interaction (PubMedID 10820259)
0

Data Source:
HPRD (two hybrid, in vitro)

		GRAP2	SOS2
Description		GRB2 related adaptor protein 2	SOS Ras/Rho guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Regulation Of MAPK Cascade	B Cell Homeostasis Lymphocyte Homeostasis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Pro-B Cell Differentiation
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Co-stimulation by CD28 FLT3 Signaling Signaling by CSF1 (M-CSF) in myeloid cells	NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 30054594 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		78 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526	20 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL DSCAM EGFR GRAP2 GRB2 HRAS ITSN1 ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9 UBASH3A
Entrez ID		9402	6655
HPRD ID		05156	03149
Ensembl ID		ENSG00000100351	ENSG00000100485
Uniprot IDs		B7Z8E3 B7Z8F8 O75791 Q6FI14	Q07890
PDB IDs		5GJH	6EIE 8T5G 8T5M 8T5R 8UC9 8UF2 8UH0 9BVE 9BVF 9BVI 9GIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signaling Adaptor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade SH2 Domain Binding Antigen Receptor-mediated Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Binding Positive Regulation Of Protein Modification Process Identical Protein Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Growth Factor Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Modification Process Lymphocyte Activation Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Leukocyte Activation Positive Regulation Of Phosphate Metabolic Process Phosphotyrosine Residue Binding Positive Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Immune Response-regulating Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cellular Component Organization Plasma Membrane Tubulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Plasma Membrane Intracellular Signal Transduction Response To Growth Factor Cytosol Proline-rich Region Binding Lipid Tube Assembly Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Vesicle Regulation Of Actin Cytoskeleton Organization Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding MAPK Cascade Regulation Of MAPK Cascade Regulation Of Immune Response Ruffle Positive Regulation Of Immune Response Cytoplasm Epidermal Growth Factor Binding Small GTPase-mediated Signal Transduction Synaptic Vesicle Endocytosis Cellular Response To Growth Factor Stimulus Endosome Regulation Of ERK1 And ERK2 Cascade Presynaptic Endocytosis Positive Regulation Of Cellular Component Biogenesis
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