CIAO1 and TOP3B

Number of citations of the paper that reports this interaction (PubMedID 34709727)
137

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, proximity labelling technology)

		CIAO1	TOP3B
Description		cytosolic iron-sulfur assembly component 1	DNA topoisomerase III beta
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GO Annotations	Cellular Component	Cytoplasm MMXD Complex Cytosolic [4Fe-4S] Assembly Targeting Complex	Condensed Chromosome Nucleus DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	Protein Binding	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Isomerase Activity RNA Topoisomerase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Chromosome Segregation Iron-sulfur Cluster Assembly Protein Maturation	DNA Topological Change DNA Repair DNA Recombination Chromosome Segregation
Pathways		Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS			Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		16 interacting genes: CCDC7 CIAO2A CIAO2B GOLM1 HAUS3 MEOX1 MEOX2 PGRMC1 RGS2 SHISA6 SLC4A7 SRPK1 TCP10L TOP3B UBC WT1	25 interacting genes: ADAMTSL4 AXIN2 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GPRASP3 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TDRD3 TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		9391	8940
HPRD ID		16057	04662
Ensembl ID		ENSG00000144021	ENSG00000100038
Uniprot IDs		O76071	A8K4N2 O95985
PDB IDs		3FM0	5GVC 5GVE 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?		Somite Specification Chromosome Segregation Cytosolic [4Fe-4S] Assembly Targeting Complex Segment Specification Somite Development
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