CYTH2 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 9476900)
0

Data Source:
HPRD (in vitro)

		CYTH2	ARFGAP1
Description		cytohesin 2	ARF GTPase activating protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction
Pathways		Intra-Golgi traffic	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Abstraction and mental flexibility ( 31596458)
Interacting Genes		30 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG SNCA TCIRG1 TRIM23	39 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23
Entrez ID		9266	55738
HPRD ID		03925	06443
Ensembl ID		ENSG00000105443	ENSG00000101199
Uniprot IDs		Q99418	Q53F62 Q8N6T3
PDB IDs		1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21	3DWD 3O47
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process	Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance
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