CYTH2 and CCDC120

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		CYTH2	CCDC120
Gene Name		cytohesin 2	coiled-coil domain containing 120
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Plasma Membrane Membrane
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Endocytosis Vesicle-mediated Transport Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ADORA2A APC ARF1 ARF6 ARFGAP1 ARRB1 ARRB2 ATP6V0A2 CCDC120 CUX1 CYTIP DYT10 GNAQ IPCEF1 ITGB2 MAPK6 PNPLA2 PRKCA PRKCB PRKCG TRIM23	18 interactors: BRCA1 CCDC102B CCDC57 CCDC85B CEP170P1 CYTH2 CYTH3 DAZAP2 EFHC2 KRT15 KRT31 KRT40 MDFI MID2 SFI1 TRAF1 USHBP1 ZDHHC17
Entrez ID		9266	90060
HPRD ID		03925	06595
Ensembl ID		ENSG00000105443	ENSG00000147144
Uniprot IDs		Q99418	A8K5Q5 B4DF24 B4DFC1 Q96HB5
PDB IDs		1PBV 1R8M 1R8Q 1R8S 1S9D
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signal Transduction Apoptotic Process Programmed Cell Death Signaling Histone H3-T6 Phosphorylation Cell Death Death Cell Communication Positive Regulation Of Metabolic Process Regulation Of Receptor Internalization Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Activation Of Phospholipase C Activity Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of Phospholipase C Activity Regulation Of Endocytosis Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Catalytic Activity Membrane Organization COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Phosphorylation Regulation Of Cellular Process Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity G-protein Coupled Receptor Internalization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Lipase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Transport Protein Localization Golgi Vesicle Budding Positive Regulation Of Cellular Metabolic Process Protein Transport Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Glucose Transport Vesicle-mediated Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Establishment Of Protein Localization	Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Histone H3-K9 Acetylation Regulation Of ARF Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Indole-3-methanol Negative Regulation Of Biosynthetic Process Negative Regulation Of Centriole Replication Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Protein Localization To Microtubule Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Metabolic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Epidermis Development
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