CYTH2 and IPCEF1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		CYTH2	IPCEF1
Description		cytohesin 2	interaction protein for cytohesin exchange factors 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding	Peroxidase Activity Oxygen Carrier Activity Protein Binding
	Biological Process	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction	Response To Oxidative Stress Oxygen Transport Cellular Oxidant Detoxification
Pathways		Intra-Golgi traffic
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Abstraction and mental flexibility ( 31596458)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Arterial stiffness index ( 31235810) Asthma ( 34103634) Asthma (childhood onset) ( 27611488) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype (sMEQ score) ( 32579418) Systemic lupus erythematosus ( 33272962)
Interacting Genes		30 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG SNCA TCIRG1 TRIM23	3 interacting genes: CEP70 CYTH2 USP7
Entrez ID		9266	26034
HPRD ID		03925	17851
Ensembl ID		ENSG00000105443	ENSG00000074706
Uniprot IDs		Q99418	Q8WWN9
PDB IDs		1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21	5MR1
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process	Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Organelle Organization Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination Negative Regulation Of Gluconeogenesis DNA Alkylation Repair Regulation Of Telomere Capping Transcription-coupled Nucleotide-excision Repair K48-linked Deubiquitinase Activity Regulation Of ARF Protein Signal Transduction Inositol 1,4,5 Trisphosphate Binding
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