CYTH2 and ATP6V0A4

Number of citations of the paper that reports this interaction (PubMedID 21307348)
75

Data Source:
BioGRID (pull down)

		CYTH2	ATP6V0A4
Description		cytohesin 2	ATPase H+ transporting V0 subunit a4
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Brush Border Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Brush Border Membrane Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V0 Domain Apical Part Of Cell Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction	Ossification Monoatomic Ion Transport Regulation Of PH Vacuolar Acidification Sensory Perception Of Sound Intracellular PH Reduction Renal Tubular Secretion Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		Intra-Golgi traffic	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A	Tiludronic acid
Diseases			Distal renal tubular acidosis (RTA type 1)
GWAS		Abstraction and mental flexibility ( 31596458)	Age-related hearing impairment ( 34108613) F-cell distribution in sickle cell anaemia ( 21326311) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		30 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG SNCA TCIRG1 TRIM23	2 interacting genes: CYTH2 PFKM
Entrez ID		9266	50617
HPRD ID		03925	05576
Ensembl ID		ENSG00000105443	ENSG00000105929
Uniprot IDs		Q99418	Q9HBG4
PDB IDs		1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21	7UNF
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process	Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Activity 6-phosphofructokinase Complex Fructose-6-phosphate Binding Fructose Binding Fructose 1,6-bisphosphate Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycogen Catabolic Process Carbohydrate Phosphorylation Fructose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Regulation Of ARF Protein Signal Transduction Inositol 1,4,5 Trisphosphate Binding Muscle Cell Cellular Homeostasis Polysaccharide Catabolic Process Sperm Principal Piece Glucose Catabolic Process ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Glycogen Metabolic Process Pyruvate Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Positive Regulation Of Insulin Secretion Nucleoside Diphosphate Metabolic Process Kinase Binding Nicotinamide Nucleotide Metabolic Process Nucleotide Catabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Carbohydrate Catabolic Process
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