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GBP2 and PPP1R8
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
GBP2
PPP1R8
Description
guanylate binding protein 2
protein phosphatase 1 regulatory subunit 8
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Spliceosomal Complex
Cytoplasm
Nuclear Speck
Molecular Function
Nucleotide Binding
GTPase Activity
Endopeptidase Inhibitor Activity
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein Homodimerization Activity
Molecular Function Inhibitor Activity
DNA Binding
RNA Binding
MRNA Binding
Nuclease Activity
Endonuclease Activity
RNA Endonuclease Activity
Protein Phosphatase Inhibitor Activity
Protein Serine/threonine Phosphatase Inhibitor Activity
Protein Binding
Ribonuclease E Activity
Hydrolase Activity
Protein Phosphatase Regulator Activity
Molecular Function Inhibitor Activity
Biological Process
Activation Of Innate Immune Response
Immune System Process
Immune Response
Protein Localization To Nucleus
Defense Response To Bacterium
Defense Response To Protozoan
Innate Immune Response
Symbiont Entry Into Host Cell
Defense Response To Gram-positive Bacterium
Protein Maturation
Defense Response To Virus
Cytolysis In Another Organism
Cellular Response To Lipopolysaccharide
Cellular Response To Type II Interferon
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of AIM2 Inflammasome Complex Assembly
MRNA Processing
RNA Catabolic Process
Cell Population Proliferation
RNA Splicing
Pathways
Interferon gamma signaling
Interferon alpha/beta signaling
CASP4 inflammasome assembly
Microbial factors inhibit CASP4 activity
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Serum metabolite levels (
33031748
)
Interacting Genes
22 interacting genes:
ANXA7
BID
BNIP3L
BTBD2
CSNK2B
FBXO7
FXR1
GADD45A
GSK3B
HSPE1
KLHL20
LSM2
MAGI1
MAPK8IP2
PAFAH1B3
PPP1R8
RPS6KA1
SAT1
SEPHS1
SERPINB9
STK3
TFG
28 interacting genes:
APP
APPBP2
CDC5L
CNKSR1
CREBBP
CRMP1
CSNK2A1
CSNK2A2
CTNNBL1
EED
ERG28
FBXO25
GBP2
HDAC2
HMGA1
LRRK2
LYN
MELK
PPIL1
PPP1CA
PPP1CC
PRKACA
RBM48
RTN4IP1
SETDB1
SF3B1
STC2
WDR77
Entrez ID
2634
5511
HPRD ID
02682
04028
Ensembl ID
ENSG00000162645
ENSG00000117751
Uniprot IDs
P32456
Q8TCE5
Q12972
Q6ICT4
PDB IDs
6VKJ
7E58
7M1S
3V4Y
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Membrane Permeability
Positive Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrial Membrane Permeability
Mitochondrial Outer Membrane Permeabilization
Positive Regulation Of Intracellular Signal Transduction
Protein Heterodimerization Activity
Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Assembly
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Organization
Mitochondrial Membrane Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Catabolic Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Protein Targeting To Mitochondrion
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Proteolysis
Protein Phosphorylation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of JNK Cascade
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Presynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Microtubule Anchoring At Centrosome
Cytoplasmic Translational Initiation
Ribonuclease E Activity
Spermidine Binding
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Type II Interferon Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Autophagy
Phosphorylation
Macromolecule Metabolic Process
Nucleoplasm
Postsynapse
Cellular Response To Catecholamine Stimulus
Response To Catecholamine
Protein Modification Process
Protein Kinase CK2 Complex
Intracellular Signal Transduction
Protein Metabolic Process
Spliceosomal Complex
Cellular Response To Stress
Regulation Of Proteolysis
Enzyme Binding
MRNA Metabolic Process
Rhythmic Process
Cellular Response To Dopamine
PTW/PP1 Phosphatase Complex
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Signaling Receptor Activator Activity
Nucleobase-containing Compound Metabolic Process
MRNA Processing
Response To Dopamine
Cellular Response To Heat
Perikaryon
Cellular Response To Manganese Ion
Chromatin Binding
Protein Kinase Activity
DNA Repair
Positive Regulation Of Gliogenesis
Regulation Of Carbohydrate Catabolic Process
Negative Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Circadian Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Programmed Cell Death
Nucleus
Response To Manganese Ion
Prp19 Complex
Protein Serine Kinase Activity
Golgi-associated Vesicle
Chromatin Organization
Regulation Of Apoptotic Process
Regulation Of Protein Catabolic Process
RNA Splicing
MRNA Splicing, Via Spliceosome
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Macroautophagy
ESC/E(Z) Complex
Negative Regulation Of Gene Expression
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Tagcloud (Intersection)
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