GBP2 and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GBP2	KLHL20
Description		guanylate binding protein 2	kelch like family member 20
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity Endopeptidase Inhibitor Activity Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Type II Interferon Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Activation Of Innate Immune Response Immune System Process Immune Response Protein Localization To Nucleus Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Symbiont Entry Into Host Cell Defense Response To Gram-positive Bacterium Protein Maturation Defense Response To Virus Cytolysis In Another Organism Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of AIM2 Inflammasome Complex Assembly	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways		Interferon gamma signaling Interferon alpha/beta signaling CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Serum metabolite levels ( 33031748)	Feeling miserable ( 29500382)
Interacting Genes		22 interacting genes: ANXA7 BID BNIP3L BTBD2 CSNK2B FBXO7 FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG	81 interacting genes: ABLIM1 ACTA1 AOC1 ARHGAP10 ARHGEF11 ARHGEF12 ARHGEF19 ATG9A BCL6 BECN1 BEX1 BEX2 C1orf216 C21orf58 CASP8AP2 CC2D1A CEP126 CIDEC CIMIP1 CLCNKA COL8A1 CORO7 CRK CRMP1 DMAC2 DUSP21 ECT2 EIF3F ENKD1 EPAS1 ERG28 F13A1 FBLN1 FHL2 FIZ1 GBE1 GBP2 GMCL1 HR IVNS1ABP JMJD1C KLHL38 KLHL9 LMO2 LRIF1 LUC7L2 MESD MTNR1A NECAB3 NEDD9 NISCH NTAQ1 NUDCD3 NUP160 ORC4 PAPPA PDPK1 PGLS PIK3C3 PIN1 PML PNKD POLR3D PRKAG1 PRMT6 RACK1 RANBP3 RECK RFC2 SGTA SLC13A5 SLC3A2 STK16 SUV39H1 SVEP1 TFAP2D TNPO2 ULK1 USP20 VPS54 ZFAT
Entrez ID		2634	27252
HPRD ID		02682	13918
Ensembl ID		ENSG00000162645	ENSG00000076321
Uniprot IDs		P32456 Q8TCE5	Q9Y2M5
PDB IDs		6VKJ 7E58 7M1S	5YQ4 6GY5 8CIA
Enriched GO Terms of Interacting Partners?		Cytoplasm Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Intracellular Signal Transduction Protein Heterodimerization Activity Regulation Of Membrane Permeability Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Assembly Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Hepatocyte Apoptotic Process Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Protein Targeting To Mitochondrion Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Proteolysis Protein Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Microtubule Anchoring At Centrosome Cytoplasmic Translational Initiation Ribonuclease E Activity Spermidine Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Type II Interferon Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Phosphorylation	Protein Binding Midbody Phagophore Assembly Site Regulation Of Cytokinesis Cytoplasm Cellular Response To Glucose Starvation Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I
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