GBP2 and SERPINB9

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GBP2	SERPINB9
Gene Name		guanylate binding protein 2, interferon-inducible	serpin peptidase inhibitor, clade B (ovalbumin), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytosol Symbiont-containing Vacuole Membrane Cytoplasmic Vesicle	Extracellular Space Nucleus Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Immune Response Metabolic Process Cytokine-mediated Signaling Pathway Cellular Response To Interferon-beta Defense Response To Protozoan Adhesion Of Symbiont To Host Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide	Mast Cell Mediated Immunity Immune Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Estrogen Stimulus
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ANXA7 BID BNIP3L BTBD2 CSNK2B FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG	27 interactors: BRD7 C14orf1 CASP4 CCDC90B COPS6 CRMP1 ECH1 EEF1A1 GAPDH GBP2 GDF9 GZMB IGSF21 LRIF1 MED31 PLEKHM1 PRPF40A RBM48 SETDB1 TLE1 TP53 TRAF5 TUBB2A UBR1 UNC119 XRCC6 ZHX1
Entrez ID		2634	5272
HPRD ID		02682	03480
Ensembl ID		ENSG00000162645	ENSG00000170542
Uniprot IDs		P32456 Q8TCE5	P50453
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of MAPK Cascade Hepatocyte Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Protein Kinase Activity Regulation Of Peptidase Activity Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Kinase Activity Regulation Of Mitochondrial Membrane Permeability Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Stress-activated MAPK Cascade Regulation Of Phosphorylation Social Behavior Positive Regulation Of Phosphorylation Response To Organic Substance	Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To X-ray Negative Regulation Of Fibroblast Proliferation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Salt Stress Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Neuron Apoptotic Process Cellular Response To Ionizing Radiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization Metabolic Process Regulation Of RNA Metabolic Process Neuron Death Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oocyte Growth Oligodendrocyte Apoptotic Process Apoptotic Process Positive Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cellular Process Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Cellular Hyperosmotic Salinity Response Cell Death Death Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Response To Osmotic Stress
Tagcloud ?		anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 cyb5a endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?