ACVR2A and INHBB

Number of citations: 0 (PubMedID 11266516)
Data Source: HPRD (in vivo)

		ACVR2A	INHBB
Name		activin A receptor type 2A	inhibin subunit beta B
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Ovarian Follicle Development Defense Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Wounding Response To Insecticide Pituitary Gland Development Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Response To Gonadotropin Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Cholesterol Seminiferous Tubule Development Cellular Response To Thyroid Hormone Stimulus Apoptotic Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling	Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs		Sotatercept	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )	Age-related macular degeneration ( 23326517 ) Breast cancer ( 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Breast size ( 22747683 27182965 ) Obesity ( 21552555 ) Serum alkaline phosphatase levels ( 33547301 ) Urate levels ( 23263486 31985003 )
Novel Interactors		1 novel interactors: BACE2	None recorded
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 CRIPTO FNTA IGSF1 INHA INHBA INHBC
Entrez ID		92	3625
HPRD ID		00025	00934
Ensembl ID		ENSG00000121989	ENSG00000163083
Uniprot IDs		P27037	P09529
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P	7U5O
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Inhibin Binding Activin Receptor Activity Growth Factor Binding Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Activin Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Activin Receptor Activity, Type II Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Ossification BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Signal Transduction Nodal Signaling Pathway System Development Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Regulation Of Bone Mineralization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling BMP Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Inhibin A Complex Protein Kinase Activity Regionalization Endothelial Cell Differentiation Cellular Response To BMP Stimulus Inhibin-betaglycan-ActRII Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Kinase Activity Positive Regulation Of Erythrocyte Differentiation