INHBB and CRIPTO

Number of citations of the paper that reports this interaction (PubMedID 28126904)
67

Data Source:
BioGRID (pull down)

		INHBB	CRIPTO
Description		inhibin subunit beta B	cripto, EGF-CFC family member
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Ovarian Follicle Development Defense Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Wounding Response To Insecticide Pituitary Gland Development Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Response To Gonadotropin Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Cholesterol Seminiferous Tubule Development Cellular Response To Thyroid Hormone Stimulus Apoptotic Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Apoptotic Signaling Pathway	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486 31985003)
Interacting Genes		12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 CRIPTO FNTA IGSF1 INHA INHBA INHBC	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		3625	6997
HPRD ID		00934	01757
Ensembl ID		ENSG00000163083	ENSG00000241186
Uniprot IDs		P09529	F5H1T8 P13385
PDB IDs		7U5O
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Inhibin Binding Activin Receptor Activity Growth Factor Binding Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Activin Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Activin Receptor Activity, Type II Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Ossification BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Signal Transduction Nodal Signaling Pathway System Development Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Regulation Of Bone Mineralization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling BMP Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Inhibin A Complex Protein Kinase Activity Regionalization Endothelial Cell Differentiation Cellular Response To BMP Stimulus Inhibin-betaglycan-ActRII Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Kinase Activity Positive Regulation Of Erythrocyte Differentiation	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis
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