ACVR2A and PRSS50

Number of citations of the paper that reports this interaction (PubMedID 28650473)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		ACVR2A	PRSS50
Description		activin A receptor type 2A	serine protease 50
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Cytoplasm Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Serine-type Endopeptidase Activity Threonine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Proteolysis
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling
Drugs		Sotatercept
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High myopia ( 31816047) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Refractive error ( 32231278) Response to statin therapy ( 20339536) Retinal detachment or retinal break ( 31816047) Urate levels ( 31985003 23263486) White blood cell count (basophil) ( 27863252)	Diastolic blood pressure ( 30224653)
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	7 interacting genes: ACVR2A CASP8 ESR2 HRAS STK11 TGFB1 TSG101
Entrez ID		92	29122
HPRD ID		00025	06405
Ensembl ID		ENSG00000121989	ENSG00000283706
Uniprot IDs		P27037	A0A140VJY3 Q9UI38
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Ossification Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Ossification Positive Regulation Of Signal Transduction Regulation Of Cell Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune System Process Response To Estradiol Apoptotic Signaling Pathway Regulation Of Cell Growth Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Hemopoiesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Development Response To Ionizing Radiation Regulation Of Signal Transduction Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Inflammatory Response Negative Regulation Of Cell Growth Cellular Response To Radiation Epithelial Cell Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Motility Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Macromolecule Metabolic Process Negative Regulation Of Growth Positive Regulation Of Developmental Process Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade
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