ACVR2A and ACVRL1

Number of citations of the paper that reports this interaction (PMID 10187774)
29

Data Source:
HPRD (in vitro)

		ACVR2A	ACVRL1
Gene Name		activin A receptor, type IIA	activin A receptor type II-like 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex	Integral Component Of Plasma Membrane Cell Surface Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To BMP Stimulus	Angiogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Heterooligomerization Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs			Adenosine triphosphate
Diseases
GWAS		Response to statin therapy ( 20339536) Urate levels ( 23263486)	Urate levels ( 23263486)
Protein-Protein Interactions		17 interactors: ACVRL1 BMP10 BMP6 BMP7 ENG ERBB2IP GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 SYNJ2BP TCTEX1D4 TGFBR3	12 interactors: ACVR2A BAMBI CSNK2B FKBP1A SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
Entrez ID		92	94
HPRD ID		00025	03181
Ensembl ID		ENSG00000121989	ENSG00000139567
Uniprot IDs		B4DWQ2 P27037	E7EN07 P37023
PDB IDs		3Q4T 3SOC 4ASX	2LCR 3MY0 4FAO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Signal Transduction Negative Regulation Of Cell Migration Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Motility Cell Differentiation Negative Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Component Movement Signaling Cell Communication Negative Regulation Of Locomotion Regulation Of Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Tissue Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Growth Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Stimulus Response To Growth Factor	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Complex Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Binding Positive Regulation Of Ossification Positive Regulation Of Protein Import Into Nucleus Skeletal System Development Response To Cholesterol Signal Transduction By Phosphorylation Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Signal Transduction
Tagcloud ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	a1cf activins ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 trim46 ube2q2 urate vegfa
Tagcloud (Difference) ?		5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423	a1cf activins ancestry atxn2 b3gnt4 baz1b consortium excretion fractional gout gugc hlf hnf4g implicate inhbb inhibins maf nfat5 painful prkag2 replicated sfmbt1 stc1 tmem171 trim46 ube2q2 urate vegfa
Tagcloud (Intersection) ?