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ACVR2A and TGFBR3
Number of citations of the paper that reports this interaction (PubMedID
10746731
)
0
Data Source:
HPRD
(in vivo)
ACVR2A
TGFBR3
Description
activin A receptor type 2A
transforming growth factor beta receptor 3
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Cell Surface
Membrane
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Basolateral Plasma Membrane
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Extracellular Exosome
Cell Periphery
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Activin Receptor Activity, Type I
Activin Receptor Activity, Type II
Transferase Activity
Activin Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Identical Protein Binding
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Transmembrane Signaling Receptor Activity
Transforming Growth Factor Beta Receptor Activity
Type II Transforming Growth Factor Beta Receptor Binding
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Glycosaminoglycan Binding
Heparin Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
PDZ Domain Binding
BMP Binding
SMAD Binding
Activin Binding
Transforming Growth Factor Beta Binding
Transforming Growth Factor Beta Receptor Activity, Type III
Biological Process
Osteoblast Differentiation
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Pattern Specification Process
Mesoderm Development
Male Gonad Development
Anterior/posterior Pattern Specification
Regulation Of Signal Transduction
Negative Regulation Of Ossification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Developmental Process
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Sperm Ejaculation
Penile Erection
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Sertoli Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Response To Hypoxia
Epithelial To Mesenchymal Transition
Liver Development
Heart Morphogenesis
Muscular Septum Morphogenesis
Outflow Tract Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Complex Assembly
Positive Regulation Of Gene Expression
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Animal Organ Regeneration
Response To Follicle-stimulating Hormone
Response To Prostaglandin E
Response To Luteinizing Hormone
Intracellular Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of JNK Cascade
Negative Regulation Of Epithelial Cell Proliferation
Ventricular Cardiac Muscle Tissue Morphogenesis
Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Definitive Hemopoiesis
Cardiac Epithelial To Mesenchymal Transition
Definitive Erythrocyte Differentiation
Heart Trabecula Formation
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Epicardium-derived Cardiac Fibroblast Cell Development
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Heart Trabecula Morphogenesis
Secondary Palate Development
Protein-containing Complex Assembly
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Extracellular Matrix Assembly
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGFBR3 regulates activin signaling
Signaling by Activin
Signaling by Activin
FGFR1b ligand binding and activation
FGFR1c ligand binding and activation
Signaling by BMP
TGF-beta receptor signaling activates SMADs
TGFBR3 PTM regulation
TGFBR3 regulates TGF-beta signaling
TGFBR3 expression
TGFBR3 regulates FGF2 signaling
TGFBR3 regulates activin signaling
Drugs
Sotatercept
Diseases
GWAS
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil count (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
Haemorrhoidal disease (
33888516
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Appendicular lean mass (
33097823
)
Bone mineral density (
19249006
)
Carotid plaque burden (
28282560
)
dexamethasone sensitivity in B-cell precursor acute lymphoblastic leukaemia (
33002292
)
Gestational age at birth (maternal effect) (
28877031
)
Glaucoma (primary open-angle) (
33627673
25861811
)
HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Heel bone mineral density (
30598549
)
HOMA-B (corrected for HOMA-IR) (
30369944
)
Lung function (FEV1/FVC) (
30804560
28166213
)
Lung function (FVC) (
26635082
30804560
)
Metamizole-induced agranulocytosis or neutropenia (
33138277
)
Multiple sclerosis (
31604244
)
Optic disc area (
25631615
21307088
28073927
31798171
)
Optic disc parameters (
20548946
)
Optic disc size (
31809533
)
Optic nerve measurement (cup-to-disc ratio) (
28061514
)
Peak expiratory flow (
30804560
)
Pulse pressure (
30224653
)
QT interval (tricyclic/tetracyclic antidepressant use interaction) (
28039329
)
Type 2 diabetes (
23209189
)
Vertical cup-disc ratio (
31798171
28073927
25241763
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
CRIPTO
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TGFBR3
13 interacting genes:
ACVR2A
ARRB2
DYNLT4
ENG
GIPC1
INHA
INHBA
NRP1
SDC2
TGFB1
TGFB2
TGFB3
TGFBR2
Entrez ID
92
7049
HPRD ID
00025
02846
Ensembl ID
ENSG00000121989
ENSG00000069702
Uniprot IDs
P27037
A0A0A8KWK3
Q03167
PDB IDs
3Q4T
3SOC
4ASX
5NH3
7U5P
7LBG
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of SMAD Protein Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Growth Factor Activity
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Cytokine Activity
Activin Receptor Signaling Pathway
Positive Regulation Of Cartilage Development
Cell Surface Receptor Signaling Pathway
Cellular Response To BMP Stimulus
Regulation Of Cartilage Development
Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Heart Development
Extracellular Space
Cellular Response To Growth Factor Stimulus
Signal Transduction
Response To Growth Factor
Positive Regulation Of Epithelial Cell Differentiation
Regulation Of Intracellular Signal Transduction
Cardiac Epithelial To Mesenchymal Transition
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Animal Organ Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Negative Regulation Of Locomotion
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Regulation Of Signal Transduction
Regulation Of Cell Migration
Epithelial To Mesenchymal Transition
Regulation Of Epithelial Cell Differentiation
BMP Receptor Binding
Positive Regulation Of BMP Signaling Pathway
Tissue Morphogenesis
Enzyme Activator Complex
Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Differentiation
Regulation Of Locomotion
Transforming Growth Factor Beta Receptor Signaling Pathway
Cartilage Development
Mesenchymal Cell Differentiation
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Type III Transforming Growth Factor Beta Receptor Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Type II Transforming Growth Factor Beta Receptor Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Type I Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Outflow Tract Septum Morphogenesis
Gland Morphogenesis
Odontogenesis
Regulation Of Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Multicellular Organismal Process
Heart Development
Regulation Of Developmental Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Animal Organ Morphogenesis
Salivary Gland Morphogenesis
Positive Regulation Of Developmental Process
Activin Binding
Response To Growth Factor
Growth Factor Activity
Negative Regulation Of Macrophage Cytokine Production
Cell Surface Receptor Signaling Pathway
Animal Organ Development
Negative Regulation Of Cytokine Production
Secondary Palate Development
Anatomical Structure Morphogenesis
Artery Morphogenesis
Vasculogenesis
Positive Regulation Of Cardiocyte Differentiation
Transforming Growth Factor Beta Receptor Binding
System Development
Cardiac Septum Morphogenesis
Response To Wounding
Roof Of Mouth Development
Cytokine Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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