ACVR2A and IGSF1

Number of citations: 0 (PubMedID 11266516)
Data Source: HPRD (in vivo)

		ACVR2A	IGSF1
Name		activin A receptor type 2A	immunoglobulin superfamily member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Extracellular Region Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Protein Binding Inhibin Binding Activin Receptor Antagonist Activity
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Immune Response-regulating Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Activin Receptor Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling	None
Drugs		Sotatercept	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )	Age at voice drop ( 27182965 ) Menarche (age at onset) ( 27182965 )
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		92	3547
HPRD ID		00025	02138
Ensembl ID		ENSG00000121989	ENSG00000147255
Uniprot IDs		P27037	Q8N6C5
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P	Not available
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Growth Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Gastrulation Inhibin Binding Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Cellular Response To Growth Factor Stimulus Regulation Of Bone Mineralization BMP Receptor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Response To Growth Factor Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Development Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Reproductive Process Negative Regulation Of Multicellular Organismal Process Skeletal System Development Receptor Complex Endothelial Cell Differentiation Cellular Response To BMP Stimulus Kinase Activity