Wiki-Pi
About
Search
People
Updates
Search
INHBB and ACVR2A
Number of citations of the paper that reports this interaction (PubMedID
11266516
)
0
Data Source:
HPRD
(in vivo)
INHBB
ACVR2A
Description
inhibin subunit beta B
activin A receptor type 2A
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Perinuclear Region Of Cytoplasm
Cell Periphery
Cytoplasm
Plasma Membrane
Cell Surface
Membrane
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Molecular Function
Cytokine Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Protein Homodimerization Activity
Host Cell Surface Receptor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Activin Receptor Activity, Type I
Activin Receptor Activity, Type II
Transferase Activity
Activin Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Identical Protein Binding
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Biological Process
Ovarian Follicle Development
Defense Response
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Male Gonad Development
Female Gonad Development
Cellular Response To Starvation
Response To Wounding
Response To Insecticide
Pituitary Gland Development
Cell Differentiation
Negative Regulation Of Hepatocyte Growth Factor Production
Cellular Response To Insulin Stimulus
Activin Receptor Signaling Pathway
Response To Gonadotropin
Cellular Response To Leptin Stimulus
Adhesion Of Symbiont To Host Cell
Fat Cell Differentiation
Negative Regulation Of Insulin Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Follicle-stimulating Hormone Secretion
Oocyte Development
Positive Regulation Of Ovulation
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Interleukin-1
Cellular Response To Cholesterol
Seminiferous Tubule Development
Cellular Response To Thyroid Hormone Stimulus
Apoptotic Signaling Pathway
Cellular Response To Thyroglobulin Triiodothyronine
Cellular Response To Phorbol 13-acetate 12-myristate
Positive Regulation Of Apoptotic Signaling Pathway
Osteoblast Differentiation
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Pattern Specification Process
Mesoderm Development
Male Gonad Development
Anterior/posterior Pattern Specification
Regulation Of Signal Transduction
Negative Regulation Of Ossification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Developmental Process
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Sperm Ejaculation
Penile Erection
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Sertoli Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Pathways
Signaling by Activin
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGFBR3 regulates activin signaling
Drugs
Sotatercept
Diseases
GWAS
Age-related macular degeneration (
23326517
)
Breast cancer (
27117709
)
Breast cancer (estrogen-receptor negative) (
27117709
)
Breast size (
22747683
27182965
)
Obesity (
21552555
)
Serum alkaline phosphatase levels (
33547301
)
Urate levels (
23263486
31985003
)
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil count (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
Haemorrhoidal disease (
33888516
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
12 interacting genes:
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
BMPR2
CRIPTO
FNTA
IGSF1
INHA
INHBA
INHBC
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
CRIPTO
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TGFBR3
Entrez ID
3625
92
HPRD ID
00934
00025
Ensembl ID
ENSG00000163083
ENSG00000121989
Uniprot IDs
P09529
P27037
PDB IDs
7U5O
3Q4T
3SOC
4ASX
5NH3
7U5P
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Activin Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Activin Receptor Complex
Enzyme-linked Receptor Protein Signaling Pathway
Inhibin Binding
Activin Receptor Activity
Growth Factor Binding
Regulation Of Activin Receptor Signaling Pathway
Activin Receptor Activity, Type I
Activin Binding
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Activin Receptor Activity, Type II
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Activin Receptor Signaling Pathway
Regulation Of Ossification
BMP Receptor Activity
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Bone Mineralization
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Ossification
Signal Transduction
Nodal Signaling Pathway
System Development
Regulation Of SMAD Protein Signal Transduction
Protein Serine/threonine Kinase Activity
Positive Regulation Of Osteoblast Differentiation
Gastrulation With Mouth Forming Second
Regulation Of Bone Mineralization
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
BMP Signaling Pathway
Determination Of Bilateral Symmetry
Determination Of Left/right Symmetry
Inhibin A Complex
Protein Kinase Activity
Regionalization
Endothelial Cell Differentiation
Cellular Response To BMP Stimulus
Inhibin-betaglycan-ActRII Complex
Negative Regulation Of Follicle-stimulating Hormone Secretion
Nodal Binding
Kinase Activity
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of SMAD Protein Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Growth Factor Activity
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Cytokine Activity
Activin Receptor Signaling Pathway
Positive Regulation Of Cartilage Development
Cell Surface Receptor Signaling Pathway
Cellular Response To BMP Stimulus
Regulation Of Cartilage Development
Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Heart Development
Extracellular Space
Cellular Response To Growth Factor Stimulus
Signal Transduction
Response To Growth Factor
Positive Regulation Of Epithelial Cell Differentiation
Regulation Of Intracellular Signal Transduction
Cardiac Epithelial To Mesenchymal Transition
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Animal Organ Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Negative Regulation Of Locomotion
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Regulation Of Signal Transduction
Regulation Of Cell Migration
Epithelial To Mesenchymal Transition
Regulation Of Epithelial Cell Differentiation
BMP Receptor Binding
Positive Regulation Of BMP Signaling Pathway
Tissue Morphogenesis
Enzyme Activator Complex
Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Differentiation
Regulation Of Locomotion
Transforming Growth Factor Beta Receptor Signaling Pathway
Cartilage Development
Mesenchymal Cell Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?