ACVR2A and GDF5

Number of citations of the paper that reports this interaction (PubMedID 8702914)
0

Data Source:
HPRD (in vivo)

		ACVR2A	GDF5
Description		activin A receptor type 2A	growth differentiation factor 5
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity BMP Binding Identical Protein Binding
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Chondrocyte Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Ossification Involved In Bone Remodeling Positive Regulation Of Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Chondroblast Differentiation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Apoptotic Process Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling	Molecules associated with elastic fibres
Drugs		Sotatercept
Diseases			Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Fibular hypoplasia and complex brachydactyly; DuPan syndrome Grebe dysplasia; Acromesomelic dysplasia Hunter-Thompson type Brachydactyly, including: Brachydactyly type C; Angel shaped phalangoepiphyseal dysplasia (ASPED)
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Arterial stiffness index ( 31235810) Asthma (adult onset) ( 31036433) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Cerebrospinal T-tau levels ( 28247064) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Feeling tense ( 29500382) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High myopia ( 31816047) Loneliness (MTAG) ( 29970889) Neutrophil percentage of granulocytes ( 27863252) Photic sneeze reflex ( 30899065) Refractive error ( 32231278) Response to statin therapy ( 20339536) Retinal detachment or retinal break ( 31816047) Urate levels ( 31985003 23263486) White blood cell count (basophil) ( 27863252)	A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Femoral neck size ( 31053729) Height ( 18391951 34270706 33713608 31562340 28552196 18391950 18391952 20189936 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Infant length ( 25281659) Intertrochanteric region size ( 31053729) Joint mobility (Beighton score) ( 27182965) Knee osteoarthritis ( 30374069 30664745) Knee pain ( 31482140) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Refractive error ( 32231278) Spine bone size ( 31053729) Trochanter size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	8 interacting genes: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1
Entrez ID		92	8200
HPRD ID		00025	03092
Ensembl ID		ENSG00000121989	ENSG00000125965
Uniprot IDs		P27037	F1T0J1 P43026
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P	1WAQ 2BHK 3EVS 3QB4 5HK5 6Z3G 6Z3H 6Z3J 6Z3L 6Z3M 7ZJF 8BWL 8BWM 8BWN 8E3G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Receptor Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Binding Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Regionalization Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Osteoblast Differentiation Animal Organ Development Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Mitral Valve Morphogenesis Pattern Specification Process Protein Serine/threonine Kinase Activity Mesoderm Development Receptor Complex Activin Binding Protein Kinase Activity Regulation Of SMAD Protein Signal Transduction Gastrulation With Mouth Forming Second Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Atrioventricular Valve Morphogenesis Cell Differentiation Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Cellular Developmental Process Ventricular Septum Morphogenesis Regulation Of Signal Transduction Mesoderm Formation Gastrulation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?