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INHBB and FNTA
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
INHBB
FNTA
Description
inhibin subunit beta B
farnesyltransferase, CAAX box, subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Perinuclear Region Of Cytoplasm
Cell Periphery
Cytoplasm
Cytosol
Microtubule Associated Complex
Plasma Membrane
CAAX-protein Geranylgeranyltransferase Complex
Protein Farnesyltransferase Complex
Molecular Function
Cytokine Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Protein Homodimerization Activity
Host Cell Surface Receptor Binding
Prenyltransferase Activity
Protein Farnesyltransferase Activity
Protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Activity
Rab Geranylgeranyltransferase Activity
Protein Binding
Microtubule Binding
Protein Prenyltransferase Activity
Acetyltransferase Activator Activity
Transferase Activity
Enzyme Binding
Receptor Tyrosine Kinase Binding
Alpha-tubulin Binding
Molecular Adaptor Activity
Biological Process
Ovarian Follicle Development
Defense Response
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Male Gonad Development
Female Gonad Development
Cellular Response To Starvation
Response To Wounding
Response To Insecticide
Pituitary Gland Development
Cell Differentiation
Negative Regulation Of Hepatocyte Growth Factor Production
Cellular Response To Insulin Stimulus
Activin Receptor Signaling Pathway
Response To Gonadotropin
Cellular Response To Leptin Stimulus
Adhesion Of Symbiont To Host Cell
Fat Cell Differentiation
Negative Regulation Of Insulin Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Follicle-stimulating Hormone Secretion
Oocyte Development
Positive Regulation Of Ovulation
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Interleukin-1
Cellular Response To Cholesterol
Seminiferous Tubule Development
Cellular Response To Thyroid Hormone Stimulus
Apoptotic Signaling Pathway
Cellular Response To Thyroglobulin Triiodothyronine
Cellular Response To Phorbol 13-acetate 12-myristate
Positive Regulation Of Apoptotic Signaling Pathway
Nuclear Envelope Organization
Enzyme-linked Receptor Protein Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Peptide Pheromone Maturation
Neuromuscular Junction Development
Protein Farnesylation
Protein Geranylgeranylation
Positive Regulation Of Rac Protein Signal Transduction
Protein Maturation
Regulation Of Microtubule-based Movement
Skeletal Muscle Acetylcholine-gated Channel Clustering
Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways
Signaling by Activin
Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
RAS processing
Potential therapeutics for SARS
Drugs
AZD3409
Lonafarnib
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
L-778123
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
Farnesyl diphosphate
Geranylgeranyl diphosphate
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS
Age-related macular degeneration (
23326517
)
Breast cancer (
27117709
)
Breast cancer (estrogen-receptor negative) (
27117709
)
Breast size (
22747683
27182965
)
Obesity (
21552555
)
Serum alkaline phosphatase levels (
33547301
)
Urate levels (
23263486
31985003
)
Zinc levels (
26025379
)
Interacting Genes
12 interacting genes:
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
BMPR2
CRIPTO
FNTA
IGSF1
INHA
INHBA
INHBC
22 interacting genes:
ACVR1
AP4M1
CENPF
CFTR
FNTB
GBP1
GRSF1
HDAC6
HRAS
INHBB
KRAS
OGT
PGGT1B
PTP4A3
RHOB
RPL13A
SAFB2
STAT2
TGFB1
TGFBR1
TGM2
VAV2
Entrez ID
3625
2339
HPRD ID
00934
00607
Ensembl ID
ENSG00000163083
ENSG00000168522
Uniprot IDs
P09529
P49354
PDB IDs
7U5O
1JCQ
1LD7
1LD8
1MZC
1S63
1SA4
1TN6
2F0Y
2H6F
2H6G
2H6H
2H6I
2IEJ
3E37
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Activin Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Activin Receptor Complex
Enzyme-linked Receptor Protein Signaling Pathway
Inhibin Binding
Activin Receptor Activity
Growth Factor Binding
Regulation Of Activin Receptor Signaling Pathway
Activin Receptor Activity, Type I
Activin Binding
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Activin Receptor Activity, Type II
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Activin Receptor Signaling Pathway
Regulation Of Ossification
BMP Receptor Activity
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Bone Mineralization
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Ossification
Signal Transduction
Nodal Signaling Pathway
System Development
Regulation Of SMAD Protein Signal Transduction
Protein Serine/threonine Kinase Activity
Positive Regulation Of Osteoblast Differentiation
Gastrulation With Mouth Forming Second
Regulation Of Bone Mineralization
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
BMP Signaling Pathway
Determination Of Bilateral Symmetry
Determination Of Left/right Symmetry
Inhibin A Complex
Protein Kinase Activity
Regionalization
Endothelial Cell Differentiation
Cellular Response To BMP Stimulus
Inhibin-betaglycan-ActRII Complex
Negative Regulation Of Follicle-stimulating Hormone Secretion
Nodal Binding
Kinase Activity
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
Tissue Morphogenesis
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Positive Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
GDP Binding
Morphogenesis Of An Epithelium
Response To Cholesterol
Protein Localization To Vacuole
Activin Receptor Signaling Pathway
Regulation Of Protein Localization
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Multicellular Organismal Process
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Prenyltransferase Activity
Response To Alcohol
Positive Regulation Of Developmental Process
Positive Regulation Of SMAD Protein Signal Transduction
Non-canonical Inflammasome Complex Assembly
Myofibroblast Differentiation
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tube Morphogenesis
Activin Receptor Complex
Activin Receptor Activity, Type I
Regulation Of Enamel Mineralization
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Developmental Process
Morphogenesis Of A Branching Epithelium
Regulation Of Establishment Of Protein Localization
Response To Lipid
Regulation Of Protein Localization To Cell Periphery
Regulation Of Programmed Cell Death
Germ Cell Migration
Morphogenesis Of A Branching Structure
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Migration
Protein Prenylation
Positive Regulation Of Cell Motility
Cellular Developmental Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Developmental Process
Prenyltransferase Activity
Regulation Of Protein Localization To Membrane
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