INHBB and ACVR1

Number of citations of the paper that reports this interaction (PMID 11266516)
5

Data Source:
HPRD (in vivo)

		INHBB	ACVR1
Gene Name		inhibin, beta B	activin A receptor, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Integral Component Of Plasma Membrane Apical Part Of Cell Activin Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Mechanical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Cell Development Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Patterning Of Blood Vessels Urogenital System Development In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Mitral Valve Morphogenesis Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Tissue Development Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Cardiac Muscle Cell Fate Commitment Endocardial Cushion Cell Fate Commitment Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis
Drugs			Adenosine triphosphate 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Obesity ( 21552555) Urate levels ( 23263486)
Protein-Protein Interactions		10 interactors: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B FNTA IGSF1 INHA INHBA INHBC	64 interactors: AP2B1 BAMBI BMP2 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FCHO1 FGD6 FKBP4 FNTA GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STX8 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		3625	90
HPRD ID		00934	00021
Ensembl ID		ENSG00000163083	ENSG00000115170
Uniprot IDs		P09529	D3DPA4 Q04771
PDB IDs			3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Mesoderm Development Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myeloid Cell Differentiation Signaling Positive Regulation Of Biomineral Tissue Development Cell Communication Gastrulation Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Gastrulation With Mouth Forming Second Regulation Of Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion SMAD Protein Signal Transduction Development Of Primary Sexual Characteristics Negative Regulation Of Hormone Secretion Hemoglobin Biosynthetic Process Cellular Response To Stimulus Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gonadotropin Secretion Positive Regulation Of Myeloid Cell Differentiation BMP Signaling Pathway Sex Differentiation Negative Regulation Of B Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Intracellular Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Metabolic Process Response To Stimulus BMP Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cell Differentiation Regulation Of Cellular Process Ras Protein Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Skeletal System Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cartilage Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Response To Organic Substance Positive Regulation Of Gene Expression Epithelium Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Connective Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation
Tagcloud ?		actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Difference) ?		actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1	advances authors braf briefly changed counterpart decades divide extremely focus gliomas helped hggs highlight histologic historically idh lethal ntrk past pdgfra pediatric phggs rarity resection subgroups telomeres tools v600e
Tagcloud (Intersection) ?