INHBB and INHA

Number of citations of the paper that reports this interaction (PMID 11134153)
10

Data Source:
HPRD (in vitro)

		INHBB	INHA
Gene Name		inhibin, beta B	inhibin, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein Heterodimerization Activity
	Biological Process	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Mechanical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Cell Development Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway	Skeletal System Development Ovarian Follicle Development Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Male Gonad Development Response To External Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Cell Development Regulation Of Cell Cycle SMAD Protein Signal Transduction
Pathways		Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis	Peptide hormone metabolism Glycoprotein hormones Peptide hormone biosynthesis
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Breast size ( 22747683) Obesity ( 21552555) Urate levels ( 23263486)
Protein-Protein Interactions		10 interactors: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B FNTA IGSF1 INHA INHBA INHBC	5 interactors: FST INHBA INHBB SIAH1 TGFBR3
Entrez ID		3625	3623
HPRD ID		00934	00933
Ensembl ID		ENSG00000163083	ENSG00000123999
Uniprot IDs		P09529	P05111
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Mesoderm Development Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myeloid Cell Differentiation Signaling Positive Regulation Of Biomineral Tissue Development Cell Communication Gastrulation Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Gastrulation With Mouth Forming Second Regulation Of Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion SMAD Protein Signal Transduction Development Of Primary Sexual Characteristics Negative Regulation Of Hormone Secretion Hemoglobin Biosynthetic Process Cellular Response To Stimulus Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gonadotropin Secretion Positive Regulation Of Myeloid Cell Differentiation BMP Signaling Pathway Sex Differentiation Negative Regulation Of B Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Female Gonad Development Development Of Primary Female Sexual Characteristics Positive Regulation Of Apoptotic Signaling Pathway Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Response To Follicle-stimulating Hormone Gonad Development Development Of Primary Sexual Characteristics Enzyme Linked Receptor Protein Signaling Pathway Activin Receptor Signaling Pathway Reproduction Sex Differentiation Regulation Of Signal Transduction Negative Regulation Of Cytokine Biosynthetic Process Negative Regulation Of Signaling Single Organism Reproductive Process Response To Gonadotropin Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Reproductive Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cell Differentiation Negative Regulation Of Hormone Secretion Ovarian Follicle Development Growth Reproductive Structure Development Reproductive System Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Hair Follicle Development Hair Cycle Process Cell Development Ovulation Cycle Process Positive Regulation Of Cell Death System Development Hemopoiesis Positive Regulation Of Hormone Secretion Gamete Generation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis Erythrocyte Differentiation
Tagcloud ?		actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1	amplification arms choosing codon considering detection fragment is6110 isoniazid katg maba mic minimum mtb multiplex pivotal primers probe qpcr refractory resistant rt snp specificity susceptible taqman thirty zone
Tagcloud (Difference) ?		actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1	amplification arms choosing codon considering detection fragment is6110 isoniazid katg maba mic minimum mtb multiplex pivotal primers probe qpcr refractory resistant rt snp specificity susceptible taqman thirty zone
Tagcloud (Intersection) ?