ACVR2A and NODAL

Number of citations: 67 (PubMedID 28126904)
Data Source: BioGRID (pull down)

		ACVR2A	NODAL
Name		activin A receptor type 2A	nodal growth differentiation factor
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Receptor Ligand Activity Type I Activin Receptor Binding
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Gastrulation With Mouth Forming Second Formation Of Primary Germ Layer Mesoderm Formation Trophectodermal Cell Differentiation Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Gastrulation Nervous System Development Brain Development Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Signal Transduction Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Cell Migration Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion Cell Differentiation Lung Development Floor Plate Morphogenesis Somatic Stem Cell Population Maintenance Embryonic Heart Tube Development Endodermal Cell Differentiation Nodal Signaling Pathway Cell Migration Involved In Gastrulation Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Cranial Skeleton Morphogenesis Tissue Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Digestive System Development Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Positive Regulation Of ERK1 And ERK2 Cascade Primitive Streak Formation Apoptotic Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance Negative Regulation Of Reproductive Process
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling	Signaling by NODAL Regulation of signaling by NODAL
Drugs		Sotatercept	None
Diseases		None	Heterotaxy; Situs ambiguus
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	6 interacting genes: ACVR1B ACVR2A ACVR2B CRIPTO KRT31 KRTAP6-3
Entrez ID		92	4838
HPRD ID		00025	08370
Ensembl ID		ENSG00000121989	ENSG00000156574
Uniprot IDs		P27037	Q96S42
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P	4N1D
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ossification Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Cellular Response To Growth Factor Stimulus Response To Growth Factor Activin Receptor Activity, Type I Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Nodal Signaling Pathway Gastrulation With Mouth Forming Second Anterior/posterior Pattern Specification Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Positive Regulation Of Erythrocyte Differentiation Regionalization Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gastrulation Regulation Of Erythrocyte Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Protein Serine/threonine Kinase Activity Pattern Specification Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Protein Kinase Activity Odontogenesis Positive Regulation Of Myeloid Cell Differentiation Anatomical Structure Morphogenesis Penile Erection Kinase Activity Positive Regulation Of Signal Transduction Cell Surface Inhibin-betaglycan-ActRII Complex Nodal Binding