ACVR2A and MAGI2

Number of citations: 0 (PubMedID 10681527)
Data Source: HPRD (two hybrid, in vitro)

		ACVR2A	MAGI2
Name		activin A receptor type 2A	membrane associated guanylate kinase, WW and PDZ domain containing 2
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Inhibin-betaglycan-ActRII Complex Receptor Complex Activin Receptor Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Activin Receptor Activity, Type I Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Identical Protein Binding Metal Ion Binding Activin Binding BMP Receptor Activity	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Osteoblast Differentiation Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Male Gonad Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Sperm Ejaculation Penile Erection Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGFBR3 regulates activin signaling	Nephrin family interactions
Drugs		Sotatercept	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Arterial stiffness index ( 31235810 ) Asthma (adult onset) ( 31036433 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 ) Cerebrospinal T-tau levels ( 28247064 ) Diastolic blood pressure ( 30224653 ) Eosinophil count ( 32888494 ) Estimated glomerular filtration rate ( 31015462 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Feeling nervous ( 29500382 ) Feeling tense ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Glomerular filtration rate (creatinine) ( 26831199 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol levels ( 32203549 ) High myopia ( 31816047 ) Loneliness (MTAG) ( 29970889 ) Neutrophil percentage of granulocytes ( 27863252 ) Photic sneeze reflex ( 30899065 ) Refractive error ( 32231278 ) Response to statin therapy ( 20339536 ) Retinal detachment or retinal break ( 31816047 ) Urate levels ( 31985003 23263486 ) White blood cell count (basophil) ( 27863252 )	Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Airway wall thickness ( 25517131 ) Bitter beverage consumption ( 31046077 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Bronchopulmonary dysplasia ( 23897914 ) Chronotype ( 30696823 ) Computer vision syndrome ( 33941792 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) General risk tolerance (MTAG) ( 30643258 ) Hippocampal atrophy ( 19668339 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lead levels in blood ( 25820613 ) Low density lipoprotein cholesterol levels ( 33339817 ) Mammographic density (dense area) ( 25342443 ) Memory dysfunction in frontotemporal lobe dementia ( 29724592 ) Metabolite levels ( 23823483 ) Nicotine dependence ( 33144568 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Response to anti-depressant treatment in major depressive disorder ( 22041458 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Schizophrenia ( 30285260 28991256 ) Serum folate levels ( 29953918 ) Total cholesterol levels ( 33339817 ) Visceral fat ( 30942860 )
Interacting Genes		23 interacting genes: ACVRL1 BMP10 BMP2 BMP4 BMP6 BMP7 CRIPTO DAXX DYNLT4 ENG ERBIN GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 NODAL PRSS50 SYNJ2BP TGFBR3	30 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
Entrez ID		92	9863
HPRD ID		00025	16212
Ensembl ID		ENSG00000121989	ENSG00000187391
Uniprot IDs		P27037	B7Z4H4 Q86UL8
PDB IDs		3Q4T 3SOC 4ASX 5NH3 7U5P	1UEP 1UEQ 1UEW 1UJV 1WFV
GO Terms Enriched among Interactors		Positive Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of SMAD Protein Signal Transduction Growth Factor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Cytokine Activity Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Cell Surface Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Cartilage Development Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Heart Development Extracellular Space Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Animal Organ Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Development Negative Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Regulation Of Cell Migration Epithelial To Mesenchymal Transition Regulation Of Epithelial Cell Differentiation BMP Receptor Binding Positive Regulation Of BMP Signaling Pathway Tissue Morphogenesis Enzyme Activator Complex Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Differentiation Regulation Of Locomotion Transforming Growth Factor Beta Receptor Signaling Pathway Cartilage Development Mesenchymal Cell Differentiation	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development