EYA2 and SIX1

Number of citations of the paper that reports this interaction (PMID 10906137)
10

Data Source:
HPRD (two hybrid)

		EYA2	SIX1
Gene Name		EYA transcriptional coactivator and phosphatase 2	SIX homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Centrosome	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Satellite Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Glaucoma (primary open-angle) ( 22419738 22570617) Optic disc size (rim) ( 20395239) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		6 interactors: DMRTB1 GNAI2 GNAZ RBPMS SIX1 SIX4	10 interactors: AES CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI TLE1 VTN
Entrez ID		2139	6495
HPRD ID		09041	03125
Ensembl ID		ENSG00000064655
Uniprot IDs		O00167	Q15475
PDB IDs		3GEB 3HB0 3HB1 4EGC	4EGC
Enriched GO Terms of Interacting Partners?		Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Olfactory Placode Formation Trigeminal Ganglion Development Myoblast Migration Fungiform Papilla Morphogenesis Fungiform Papilla Development Ganglion Development Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Tongue Morphogenesis Nose Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development Positive Regulation Of Embryonic Development Positive Regulation Of Kidney Development Tongue Development Muscle Cell Migration Cranial Nerve Development Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Thymus Development Regulation Of Synapse Assembly Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Tissue Development Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Nerve Development Somite Development Inner Ear Morphogenesis Metanephros Development Regulation Of Embryonic Development Ear Morphogenesis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Embryonic Skeletal System Morphogenesis Regulation Of Striated Muscle Tissue Development Negative Regulation Of Satellite Cell Differentiation Skeletal Muscle Fiber Differentiation Skeletal Muscle Tissue Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Skeletal Muscle Organ Development Regulation Of Protein Localization Embryonic Skeletal System Development Protein Localization To Nucleus Negative Regulation Of Neuron Apoptotic Process Regulation Of Organ Morphogenesis Inner Ear Development	Histone Dephosphorylation Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Developmental Process Peptidyl-tyrosine Dephosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dephosphorylation Regulation Of RNA Metabolic Process Embryonic Morphogenesis RNA Metabolic Process Multicellular Organismal Development Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Anoikis Dephosphorylation Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Middle Ear Morphogenesis Nucleobase-containing Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process DNA Repair Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Positive Regulation Of DNA Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Regulation Of Wnt Signaling Pathway Nitrogen Compound Metabolic Process Embryonic Organ Morphogenesis Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair
Tagcloud ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc gas7 glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?