EYA2 and DMRTB1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EYA2	DMRTB1
Gene Name		EYA transcriptional coactivator and phosphatase 2	DMRT-like family B with proline-rich C-terminal, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Centrosome	Nucleus
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Sex Differentiation
Pathways
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Response to statin therapy ( 20339536)
Protein-Protein Interactions		6 interactors: DMRTB1 GNAI2 GNAZ RBPMS SIX1 SIX4	13 interactors: CTBP1 CTBP2 EWSR1 EYA2 IL16 LENG8 NCKIPSD NIF3L1 PRMT2 RBFOX1 RBFOX2 SORBS3 VASP
Entrez ID		2139	63948
HPRD ID		09041	16828
Ensembl ID		ENSG00000064655	ENSG00000143006
Uniprot IDs		O00167	Q96MA1
PDB IDs		3GEB 3HB0 3HB1 4EGC
Enriched GO Terms of Interacting Partners?		Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Olfactory Placode Formation Trigeminal Ganglion Development Myoblast Migration Fungiform Papilla Morphogenesis Fungiform Papilla Development Ganglion Development Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Tongue Morphogenesis Nose Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development Positive Regulation Of Embryonic Development Positive Regulation Of Kidney Development Tongue Development Muscle Cell Migration Cranial Nerve Development Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Thymus Development Regulation Of Synapse Assembly Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Tissue Development Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Nerve Development Somite Development Inner Ear Morphogenesis Metanephros Development Regulation Of Embryonic Development Ear Morphogenesis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Embryonic Skeletal System Morphogenesis Regulation Of Striated Muscle Tissue Development Negative Regulation Of Satellite Cell Differentiation Skeletal Muscle Fiber Differentiation Skeletal Muscle Tissue Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Skeletal Muscle Organ Development Regulation Of Protein Localization Embryonic Skeletal System Development Protein Localization To Nucleus Negative Regulation Of Neuron Apoptotic Process Regulation Of Organ Morphogenesis Inner Ear Development	Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuromuscular Process Controlling Balance Cellular Nitrogen Compound Metabolic Process Histone Modification Positive Regulation Of Organelle Organization 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of RNA Splicing Dihydrobiopterin Metabolic Process Nitrogen Compound Metabolic Process Fat Cell Differentiation Neuromuscular Process Viral Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Histone Dephosphorylation Positive Regulation Of Chromatin Binding Chromatin Modification Nucleobase-containing Compound Metabolic Process Mesodermal Cell Fate Specification Cell Differentiation Transcription, DNA-templated Viral Life Cycle RNA Biosynthetic Process Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Histone H4 Acetylation Chromatin Organization Mitochondrial Outer Membrane Permeabilization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Tagcloud ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Difference) ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish
Tagcloud (Intersection) ?