EYA2 and GNAI2

Number of citations of the paper that reports this interaction (PubMedID 10906137)
0

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		EYA2	GNAI2
Description		EYA transcriptional coactivator and phosphatase 2	G protein subunit alpha i2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle
	Molecular Function	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Mesodermal Cell Fate Specification Striated Muscle Tissue Development Cell Differentiation Positive Regulation Of DNA Repair Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases			Adrenal carcinoma
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Body fat percentage and triglycerides (pairwise) ( 33619380) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) Fasting insulin ( 34059833) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (FVC) ( 30804560 30061609) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		36 interacting genes: AATK ATOSB BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FBXO7 GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C	66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A
Entrez ID		2139	2771
HPRD ID		09041	00764
Ensembl ID		ENSG00000064655	ENSG00000114353
Uniprot IDs		E7ETN2 O00167	B3KP24 B3KX51 P04899
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA 7F8G 7F8H	6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV
Enriched GO Terms of Interacting Partners?		Sperm Flagellum Fungiform Papilla Morphogenesis Sperm Motility Motile Cilium Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Cellular Component Assembly Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Organelle Assembly Axonemal A Tubule Inner Sheath Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cilium Cilium Movement Cranial Ganglion Development Tongue Development Metanephric Mesenchyme Development Positive Regulation Of Epithelial Tube Formation Microtubule-based Movement Regulation Of Synaptic Assembly At Neuromuscular Junction Cilium Assembly Microtubule-based Process Myoblast Migration Reproductive Process Cilium Organization Ciliary Basal Body Vesicle Organization Ganglion Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Guanyl Nucleotide Binding Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Animal Organ Morphogenesis Pharyngeal System Development Generation Of Neurons Plasma Membrane Bounded Cell Projection Assembly Regulation Of Branching Involved In Ureteric Bud Morphogenesis Protein Targeting G-protein Beta/gamma-subunit Complex Binding Cell Projection Assembly Regulation Of Skeletal Muscle Cell Differentiation COPII Vesicle Coating Muscle Cell Cellular Homeostasis Protein Binding Cell Motility Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Muscle Cell Migration Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction
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