EYA2 and SIX4

Number of citations of the paper that reports this interaction (PMID 10490620)
53

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		EYA2	SIX4
Gene Name		EYA transcriptional coactivator and phosphatase 2	SIX homeobox 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Centrosome	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Tyrosine Phosphatase Activity Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mesodermal Cell Fate Specification Striated Muscle Tissue Development Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization	Transcription, DNA-templated Skeletal Muscle Tissue Development Regulation Of Synaptic Growth At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		6 interactors: DMRTB1 GNAI2 GNAZ RBPMS SIX1 SIX4	2 interactors: EYA2 EYA3
Entrez ID		2139	51804
HPRD ID		09041	06960
Ensembl ID		ENSG00000064655	ENSG00000100625
Uniprot IDs		O00167	Q9UIU6
PDB IDs		3GEB 3HB0 3HB1 4EGC
Enriched GO Terms of Interacting Partners?		Myotome Development Positive Regulation Of Ureteric Bud Formation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Regulation Of Synaptic Growth At Neuromuscular Junction Olfactory Placode Formation Trigeminal Ganglion Development Myoblast Migration Fungiform Papilla Morphogenesis Fungiform Papilla Development Ganglion Development Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Metanephric Mesenchyme Development Tongue Morphogenesis Nose Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Pharyngeal System Development Positive Regulation Of Embryonic Development Positive Regulation Of Kidney Development Tongue Development Muscle Cell Migration Cranial Nerve Development Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Thymus Development Regulation Of Synapse Assembly Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Regulation Of Skeletal Muscle Tissue Development Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Nerve Development Somite Development Inner Ear Morphogenesis Metanephros Development Regulation Of Embryonic Development Ear Morphogenesis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Embryonic Skeletal System Morphogenesis Regulation Of Striated Muscle Tissue Development Negative Regulation Of Satellite Cell Differentiation Skeletal Muscle Fiber Differentiation Skeletal Muscle Tissue Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Skeletal Muscle Organ Development Regulation Of Protein Localization Embryonic Skeletal System Development Protein Localization To Nucleus Negative Regulation Of Neuron Apoptotic Process Regulation Of Organ Morphogenesis Inner Ear Development	Histone Dephosphorylation Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Histone Modification Dephosphorylation Mesodermal Cell Fate Specification DNA Repair Chromatin Modification Mitochondrial Outer Membrane Permeabilization Chromatin Organization Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Mesodermal Cell Fate Commitment Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Chromosome Organization DNA Metabolic Process Mesodermal Cell Differentiation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of DNA Repair Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Mitochondrial Membrane Organization Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Mitochondrial Changes Mesoderm Formation Mesoderm Morphogenesis Cell Fate Specification Extrinsic Apoptotic Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis Regulation Of Response To DNA Damage Stimulus Formation Of Primary Germ Layer Response To Ionizing Radiation Mesoderm Development Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Mitochondrial Transport Visual Perception Sensory Perception Of Light Stimulus Phosphate-containing Compound Metabolic Process Gastrulation Organelle Organization RNA Metabolic Process Cellular Protein Modification Process Response To Stress
Tagcloud ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	antagonistically bivalent catalysed catalysing demethylases demethylation elongation facilitates h3k27 h3k27me3 h3k4me3 lys27 lys4 marks myogenesis pcg pol polycomb recruits remove replaced repressive spreading transactivator transcribed trimethylation trithorax trxg utx
Tagcloud (Difference) ?		atoh1 atoh1a atoh1and conditional coregulate crest determinant ear elusive fate fgf fgfr fgfs ganglia hair ontogeny otic postfertilization sag segmentation seq sox9 sox9a specify statoacoustic tlx2 ultricular uncovered zebrafish	antagonistically bivalent catalysed catalysing demethylases demethylation elongation facilitates h3k27 h3k27me3 h3k4me3 lys27 lys4 marks myogenesis pcg pol polycomb recruits remove replaced repressive spreading transactivator transcribed trimethylation trithorax trxg utx
Tagcloud (Intersection) ?