EYA2 and DTX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EYA2	DTX2
Description		EYA transcriptional coactivator and phosphatase 2	deltex E3 ubiquitin ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Magnesium Ion Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Histone H2AXY142 Phosphatase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair Chromatin Organization Chromatin Remodeling DNA Damage Response Mesodermal Cell Fate Specification Striated Muscle Tissue Development Cell Differentiation Positive Regulation Of DNA Repair Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Notch Signaling Pathway Protein Ubiquitination
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 31361310) Asthma ( 32296059) Body fat percentage and triglycerides (pairwise) ( 33619380) Brain volume in infants (intracranial brain volume) ( 28763065) Coffee consumption ( 31046077) Fasting insulin ( 34059833) FEV1 ( 30804560) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (FVC) ( 30804560 30061609) Non-del(5q) myelodysplastic syndromes ( 31738830) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 30054458 30297969) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		36 interacting genes: AATK ATOSB BAG3 CATSPER1 CDK18 DMRTB1 DTX2 DUSP21 ENKD1 FBXO7 GNAI2 GNAZ HGS IQUB LGALS4 MED25 PATZ1 PAX9 PIN1 POGZ RBPMS RFX2 ROR2 SIX1 SIX4 SNRPC SPG21 SUOX TEKT4 TEKT5 TFG TLE5 TRAF4 TRAPPC6A TSSK3 VPS37C	135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		2139	113878
HPRD ID		09041	16841
Ensembl ID		ENSG00000064655	ENSG00000091073
Uniprot IDs		E7ETN2 O00167	Q86UW9
PDB IDs		3GEB 3HB0 3HB1 4EGC 5ZMA 7F8G 7F8H	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?		Sperm Flagellum Fungiform Papilla Morphogenesis Sperm Motility Motile Cilium Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Cellular Component Assembly Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Organelle Assembly Axonemal A Tubule Inner Sheath Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development Cilium Cilium Movement Cranial Ganglion Development Tongue Development Metanephric Mesenchyme Development Positive Regulation Of Epithelial Tube Formation Microtubule-based Movement Regulation Of Synaptic Assembly At Neuromuscular Junction Cilium Assembly Microtubule-based Process Myoblast Migration Reproductive Process Cilium Organization Ciliary Basal Body Vesicle Organization Ganglion Development Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Guanyl Nucleotide Binding Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Animal Organ Morphogenesis Pharyngeal System Development Generation Of Neurons Plasma Membrane Bounded Cell Projection Assembly Regulation Of Branching Involved In Ureteric Bud Morphogenesis Protein Targeting G-protein Beta/gamma-subunit Complex Binding Cell Projection Assembly Regulation Of Skeletal Muscle Cell Differentiation COPII Vesicle Coating Muscle Cell Cellular Homeostasis Protein Binding Cell Motility Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Muscle Cell Migration Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity
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