FEZ1 and DIS3L2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FEZ1	DIS3L2
Gene Name		fasciculation and elongation protein zeta 1 (zygin I)	DIS3 like 3-5 exoribonuclease 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite	Cytoplasmic MRNA Processing Body Cytoplasm Polysome
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	3'-5'-exoribonuclease Activity Magnesium Ion Binding Ribonuclease Activity Protein Binding Poly(U) RNA Binding
	Biological Process	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Mitotic Nuclear Division Negative Regulation Of Cell Proliferation MiRNA Catabolic Process Stem Cell Maintenance Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Cell Division Mitotic Sister Chromatid Separation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Polyuridylation-dependent MRNA Catabolic Process
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 22688191 23894747)	Height ( 23563607 19570815 18391951 20189936)
Protein-Protein Interactions		57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	3 interactors: COPS6 FEZ1 VIM
Entrez ID		9638	129563
HPRD ID		09212	14619
Ensembl ID		ENSG00000149557	ENSG00000144535
Uniprot IDs		Q99689	Q8IYB7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated	Regulation Of Neuron Projection Development Bergmann Glial Cell Differentiation Cullin Deneddylation Regulation Of Cell Projection Organization Protein Deneddylation Regulation Of Neuron Differentiation Viral Process Negative Regulation Of Macroautophagy Establishment Of Mitochondrion Localization Intermediate Filament Organization Lens Fiber Cell Development Regulation Of Neurogenesis Astrocyte Development Regulation Of Cell Development Muscle Filament Sliding Actin-myosin Filament Sliding Negative Regulation Of Autophagy Lens Fiber Cell Differentiation Mitochondrion Localization Intermediate Filament Cytoskeleton Organization Astrocyte Differentiation Intermediate Filament-based Process Actin-mediated Cell Contraction SMAD Protein Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Regulation Of Dendrite Morphogenesis Execution Phase Of Apoptosis
Tagcloud ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365	biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx
Tagcloud (Difference) ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365	biallelic degrades deleting dicer drosha enforced enu establishing exonuclease igf2 illustrated imprinting intense let lin28 mirna nephroblastoma noting opportunity pivotal predisposition recapitulates renewal rnases thirds wilms worth wt1 wtx
Tagcloud (Intersection) ?