FEZ1 and TOMM20

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FEZ1	TOMM20
Gene Name		fasciculation and elongation protein zeta 1 (zygin I)	translocase of outer mitochondrial membrane 20 homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite	Mitochondrion Mitochondrial Outer Membrane Translocase Complex Integral Component Of Membrane ER-mitochondrion Membrane Contact Site
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	Protein Binding P-P-bond-hydrolysis-driven Protein Transmembrane Transporter Activity Unfolded Protein Binding
	Biological Process	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Protein Transmembrane Transport
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS		Schizophrenia ( 22688191 23894747)	Cholesterol, total ( 20686565) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) Obesity-related traits ( 23251661)
Protein-Protein Interactions		57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	17 interactors: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 DHFR FEZ1 HAP1 KIAA1377 OTC PPHLN1 PTN TOMM22 TOMM40 UCP1 VDAC1
Entrez ID		9638	9804
HPRD ID		09212	03507
Ensembl ID		ENSG00000149557	ENSG00000173726
Uniprot IDs		Q99689	Q15388
PDB IDs			4APO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated	Mitochondrial Transport Cellular Localization Regulation Of Protein Stability Establishment Of Localization In Cell Developmental Process Anatomical Structure Development Posttranscriptional Regulation Of Gene Expression Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Intracellular Transport Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Learning Mitochondrion Organization Regulation Of Mitotic Cell Cycle Cell Differentiation Cell Cycle Single-organism Behavior Negative Regulation Of Autophagy Response To Organic Cyclic Compound Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Behavioral Fear Response Regulation Of Cell Cycle Process Positive Regulation Of Cell Development Fear Response Protein Localization To Organelle Response To Drug Axon Regeneration Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Anion Homeostasis Organ Development Regulation Of Cell Cycle Phase Transition Neuron Projection Regeneration Behavior Organelle Organization Ornithine Catabolic Process Negative Regulation Of Cellular PH Reduction Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Retinal Cell Programmed Cell Death Negative Regulation Of Cell Adhesion Molecule Production Learning Or Memory Protein Transmembrane Transport System Development Mitochondrial Membrane Organization
Tagcloud ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Difference) ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365
Tagcloud (Intersection) ?