FEZ1 and WWC1

Number of citations of the paper that reports this interaction (PMID 16484223)
14

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		FEZ1	WWC1
Gene Name		fasciculation and elongation protein zeta 1 (zygin I)	WW and C2 domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Microtubule Plasma Membrane Microtubule Cytoskeleton Axon Dendrite	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase C Binding Protein Binding Gamma-tubulin Binding Protein N-terminus Binding	Transcription Coactivator Activity Protein Binding Kinase Binding Protein Binding, Bridging Protein Complex Scaffold
	Biological Process	Transport Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Neuron Projection Development Establishment Of Mitochondrion Localization Cellular Response To Growth Factor Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of Organ Growth
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Schizophrenia ( 22688191 23894747)	Periodontal microbiota ( 22699663)
Protein-Protein Interactions		57 interactors: BARD1 BORA BRD1 C16orf59 C8orf33 CCL7 CIB1 CLASP2 COL9A2 CSTF2 DIS3L2 DISC1 DNAAF5 DRAP1 FEZ2 GEMIN7 GTF2F1 HAP1 HTATSF1 HTT IMMT KIAA1377 LRIF1 MEST NBR1 NDUFB9 NEK1 OLFML3 P4HB PAM16 PDCD7 PRKCZ PTH PTN PTPRS RAB3GAP1 RAB3GAP2 RAI14 RIF1 SAP30L SCOC SERPINH1 SMARCD1 SMC3 SMEK2 STAR TAC3 TAF1D TAF9 TBC1D25 TLK2 TOMM20 TTR TXNDC9 UBE4B WWC1 ZNF251	13 interactors: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 HIST1H3A KIAA0513 LRIF1 MAPK6 PRKCZ TNIK
Entrez ID		9638	23286
HPRD ID		09212	10033
Ensembl ID		ENSG00000149557	ENSG00000113645
Uniprot IDs		Q99689	Q8IX03
PDB IDs			2Z0U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Organelle Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Regulation Of Cellular Process Vesicle Transport Along Microtubule Cell Cycle Mitotic Cell Cycle Microtubule-based Process Microtubule Cytoskeleton Organization Regulation Of Metabolic Process Response To Radiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Heterocycle Metabolic Process Cellular Process Cellular Homeostasis Organelle Transport Along Microtubule Positive Regulation Of Metabolic Process Response To Ionizing Radiation Response To Stimulus Movement Of Cell Or Subcellular Component Cell Division Regulation Of Intracellular Signal Transduction Cell Cycle Process Regulation Of Synaptic Plasticity Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Synaptic Transmission Regulation Of Microtubule-based Process Response To Abiotic Stimulus Cellular Nitrogen Compound Metabolic Process Establishment Or Maintenance Of Cell Polarity Cellular Metabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Process Homeostatic Process Regulation Of Signal Transduction Regulation Of Signaling Mitochondrial Calcium Ion Homeostasis Regulation Of Organelle Organization Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Component Organization Nitrogen Compound Metabolic Process DNA-templated Transcription, Elongation Establishment Of Protein Localization To Organelle Anatomical Structure Development Nervous System Development RNA Metabolic Process Diencephalon Development Transcription, DNA-templated	Regulation Of Nitrogen Compound Metabolic Process Actin Cytoskeleton Reorganization Generation Of Neurons Regulation Of Dendrite Morphogenesis Neurogenesis Regulation Of Cellular Process Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Regulation Of Transcription, DNA-templated Regulation Of Dendrite Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Regulation Of RNA Metabolic Process Cell Projection Organization Cellular Metabolic Process Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production Nucleobase-containing Compound Metabolic Process Response To Stimulus Protein Localization To Plasma Membrane Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Activation Of Phospholipase D Activity Nervous System Development Regulation Of Gene Expression Transcription, DNA-templated Cellular Response To Stimulus Cell Cycle Neuron Projection Morphogenesis Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Interleukin-13 Production DNA Packaging Signal Transduction Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Interleukin-5 Production Positive Regulation Of Cellular Metabolic Process Positive Regulation Of T Cell Cytokine Production Histone H2B Ubiquitination Regulation Of Cell Differentiation Plasma Membrane Organization Positive Regulation Of T-helper 2 Cell Differentiation DNA Replication-dependent Nucleosome Assembly Activation Of JNKK Activity Nitrogen Compound Metabolic Process
Tagcloud ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk3 stk4 vapsbinding wwc2 wwtr1 yap1
Tagcloud (Difference) ?		atf5 burden credible disc1 disordered endophenotypes highlighting intriguing intrinsically lis maf missense nde1 ndel1 neuropsychiatric partners pde4b psychiatric reside schizophrenia striking swedish synonymous sz traf3ip1 unexplored variants ywhae znf365	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk3 stk4 vapsbinding wwc2 wwtr1 yap1
Tagcloud (Intersection) ?