FOXL2

Name	forkhead box L2
Structure
Interactors	3 interactors: LATS1 PAK1 UBE2I
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Flemming Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Estrogen Receptor Binding Ubiquitin Conjugating Enzyme Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Oocyte Growth Extraocular Skeletal Muscle Development Apoptotic DNA Fragmentation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Single Fertilization Female Gonad Development Anatomical Structure Morphogenesis Female Somatic Sex Determination Cell Differentiation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Follicle-stimulating Hormone Secretion Embryonic Eye Morphogenesis Granulosa Cell Differentiation Uterus Development
Pathways	SUMOylation of transcription factors
Diseases	Premature ovarian failure Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES)
GWAS	Ear morphology ( 26105758 ) Eyebrow thickness ( 26926045 30248107 ) Keloid ( 20711176 ) Lobe attachment (rater scored) ( 29198719 ) Lobe attachment (rater-scored or self-reported) ( 29198719 ) Lobe size ( 26105758 ) Male-pattern baldness ( 28196072 )
Entrez ID	668
HPRD ID	05723
Ensembl ID	ENSG00000183770
Uniprot IDs	P58012 Q53ZD3
PDB IDs	7VOU 7VOV
GO Terms Enriched among Interactors ?	Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Organ Growth Chromosome Segregation SUMO Conjugating Enzyme Activity ATP Binding Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly RING-like Zinc Finger Domain Binding Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Actin Filament Organization SUMO Ligase Complex HLH Domain Binding Positive Regulation Of Signal Transduction Nucleotide Binding Regulation Of Developmental Growth Transferase Activity Small Protein Activating Enzyme Binding Positive Regulation Of Microtubule Nucleation Protein Serine Kinase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Regulation Of Actin Filament-based Process Protein Localization To Cytoplasmic Stress Granule Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Nuclear Membrane Reassembly Regulation Of Protein-containing Complex Assembly Positive Regulation Of Locomotion Regulation Of Microtubule Nucleation Positive Regulation Of Cellular Component Biogenesis Protein Kinase Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Growth Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Kinase Activity Cellular Response To Lectin Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway