PTEN and MVP

Number of citations of the paper that reports this interaction (PMID 12177006)
22

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PTEN	MVP
Gene Name		phosphatase and tensin homolog	major vault protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Postsynaptic Membrane	Nucleus Nuclear Pore Cytoplasm Cytoskeleton Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Enzyme Binding Protein Kinase Binding PDZ Domain Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity	Protein Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Regulation Of B Cell Apoptotic Process Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Activation Of APC-Cdc20 Complex Activity Epidermal Growth Factor Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Synapse Assembly Central Nervous System Development Heart Development Aging Response To Nutrient Learning Or Memory Memory Locomotory Behavior Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Response To Zinc Ion Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell Migration Negative Regulation Of Myelination Regulation Of Protein Stability Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Central Nervous System Myelin Maintenance Response To Estradiol Regulation Of Cellular Component Size Regulation Of Myeloid Cell Apoptotic Process Response To ATP Multicellular Organismal Response To Stress Social Behavior Peptidyl-tyrosine Dephosphorylation Fc-epsilon Receptor Signaling Pathway Response To Drug Maternal Behavior Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Response To Ethanol Locomotor Rhythm Negative Regulation Of Cell Size Negative Regulation Of Organ Growth Response To Arsenic-containing Substance Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cardiac Muscle Tissue Development Forebrain Morphogenesis Brain Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phagocytosis Negative Regulation Of Axonogenesis Protein Stabilization T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase B Signaling Rhythmic Synaptic Transmission Canonical Wnt Signaling Pathway Synapse Maturation Prepulse Inhibition Male Mating Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Prostate Gland Growth Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Ribosome Biogenesis Negative Regulation Of Cell Aging Negative Regulation Of Excitatory Postsynaptic Membrane Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Apoptotic Signaling Pathway	Cell Proliferation Protein Transport Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Metabolism of lipids and lipoproteins Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Synthesis of PIPs at the plasma membrane Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Synthesis of IP3 and IP4 in the cytosol PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Phospholipid metabolism PI Metabolism Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Inositol phosphate metabolism PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR TCR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: AKT1 ANG AR CAV1 CDC27 CHGB COPS6 CSNK2A1 CSNK2A2 DLG1 ESR1 FZR1 HBA1 LATS1 MAGI2 MAGI3 MAST1 MAST2 MAST3 MVP NDFIP1 NEDD4 PARK7 PPP1CA PXN SLC9A3R1 SLC9A3R2 STK11 TP53 UBE2I UBE2L3 USP13 UTP14A WWP1	57 interactors: ADAMTSL4 AES BANP BZRAP1 C1orf94 CALCOCO2 CAMK2B CCDC36 CKAP4 CYTB DISC1 DLX2 EPHX2 ESR1 FAM154A FAM46C GIT2 GOLGA2 HP KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MKL1 NNT NOTCH2NL OBFC1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SERTAD1 SKIL SLC2A4 TCF4 TFCP2 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 VAC14 ZBTB32 ZMIZ2
Entrez ID		5728	9961
HPRD ID		03431	05475
Ensembl ID			ENSG00000013364
Uniprot IDs		F6KD01 P60484	B4DP93 Q14764
PDB IDs		1D5R 2KYL	1Y7X
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Signal Transduction Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Metabolic Process Positive Regulation Of Phosphorylation Mitotic Cell Cycle Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Protein Complex Assembly Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Negative Regulation Of Protein Metabolic Process Cell Communication Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Catabolic Process Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Cytokine RNA Metabolic Process Defense Response Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Apoptotic Process Protein Localization To Nucleus Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Difference) ?		10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Intersection) ?