ALPP and LCE3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALPP	LCE3B
Description		alkaline phosphatase, placental	late cornified envelope 3B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding	Protein Binding
	Biological Process		Epidermis Development Keratinization Killing Of Cells Of Another Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Intra-Golgi traffic	Formation of the cornified envelope
Drugs		Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases
GWAS		Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Psoriasis ( 23143594)
Interacting Genes		47 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1	45 interacting genes: ALPP CYP21A2 CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE5A RGS17 RNF4 SMCP TGFB1 UBE2I ZMYM5
Entrez ID		250	353143
HPRD ID		01379	13974
Ensembl ID		ENSG00000163283	ENSG00000187238
Uniprot IDs		B2R7C7 P05187	Q5TA77
PDB IDs		1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Identical Protein Binding Cytosol
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