PAPSS1

Gene Name		3-phosphoadenosine 5-phosphosulfate synthase 1
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity ATP Binding Nucleotidyltransferase Activity
	Biological Process	Sulfate Assimilation Skeletal System Development Carbohydrate Metabolic Process Xenobiotic Metabolic Process Pathogenesis Phosphorylation Glycosaminoglycan Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) MPS IIIC - Sanfilippo syndrome C Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Phase II conjugation Transport and synthesis of PAPS Cytosolic sulfonation of small molecules Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Transport and synthesis of PAPS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: EEF1A1 PPP1R16A UNC119
Entrez ID		9061
HPRD ID		09132
Ensembl ID		ENSG00000138801
Uniprot IDs		O43252 Q6IAX6
PDB IDs		1X6V 1XJQ 1XNJ 2OFW 2OFX 2PEY 2PEZ 2QJF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Protein Tyrosine Kinase Activity Mitotic Cytokinesis Negative Regulation Of Endocytosis Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		adenovirus adjacent arresting believed catalyzing cck comparatively cycles discrepancies downregulating endometrial estrogen estrogens expressions mcf meanwhile proliferating prominent retarded subcutaneous sulfate sulfation sult1e1 tumorous universal upregulating xenograft