PAPSS1

Description		3'-phosphoadenosine 5'-phosphosulfate synthase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nucleotidyltransferase Activity Protein Homodimerization Activity
	Biological Process	Sulfate Assimilation Skeletal System Development 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways		Transport and metabolism of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Signaling by BRAF and RAF1 fusions
Drugs		Adenosine-5'-diphosphate-2',3'-vanadate Adenosine 5'-phosphosulfate Glycerin
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Telomere length ( 24478790)
Novel Interacting Genes		1 novel interacting genes: LARP7
Interacting Genes		4 interacting genes: EEF1A1 ERRFI1 PPP1R16A UNC119
Entrez ID		9061
HPRD ID		09132
Ensembl ID		ENSG00000138801
Uniprot IDs		O43252
PDB IDs		1X6V 1XJQ 1XNJ 2OFW 2OFX 2PEY 2PEZ 2QJF 8I1M
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation U6 2'-O-snRNA Methylation Kinase Binding Negative Regulation Of Caveolin-mediated Endocytosis Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Eukaryotic Translation Elongation Factor 1 Complex Negative Regulation Of Clathrin-dependent Endocytosis Box C/D Sno(s)RNA 3'-end Processing Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Response To Growth Factor Cellular Response To Growth Factor Stimulus Kinase Activator Activity Host-mediated Perturbation Of Viral Genome Replication Cytoplasmic Side Of Lysosomal Membrane Host-mediated Activation Of Viral Genome Replication Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Tyrosine Kinase Activity SnRNA Modification 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body U6 SnRNA Binding Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Limb Joint Morphogenesis Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Myosin Phosphatase Regulator Activity Chondrocyte Proliferation Lung Epithelium Development Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Viral Transcription Translation Elongation Factor Activity Lipoprotein Transport Regulation Of Protein Phosphorylation
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