PAPSS1 and PPP1R16A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAPSS1	PPP1R16A
Gene Name		3-phosphoadenosine 5-phosphosulfate synthase 1	protein phosphatase 1, regulatory subunit 16A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Plasma Membrane
	Molecular Function	Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity ATP Binding Nucleotidyltransferase Activity	Protein Binding
	Biological Process	Sulfate Assimilation Skeletal System Development Carbohydrate Metabolic Process Xenobiotic Metabolic Process Pathogenesis Phosphorylation Glycosaminoglycan Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective UGT1A1 causes hyperbilirubinemia Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) MPS IIIC - Sanfilippo syndrome C Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Phase II conjugation Transport and synthesis of PAPS Cytosolic sulfonation of small molecules Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Transport and synthesis of PAPS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: EEF1A1 PPP1R16A UNC119	20 interactors: AES CDH24 DDX27 FAM101B FSD1 HGS HLA-E IDO1 LY6H PAPSS1 PBDC1 PHPT1 PPP1CA PPP1CB PPP1CC PUF60 RGMA TPP2 TRIP6 TXNRD1
Entrez ID		9061	84988
HPRD ID		09132	16454
Ensembl ID		ENSG00000138801	ENSG00000160972
Uniprot IDs		O43252 Q6IAX6	Q96I34
PDB IDs		1X6V 1XJQ 1XNJ 2OFW 2OFX 2PEY 2PEZ 2QJF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Positive Regulation Of Protein Tyrosine Kinase Activity Mitotic Cytokinesis Negative Regulation Of Endocytosis Regulation Of Protein Tyrosine Kinase Activity	Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Regulation Of Glycogen Catabolic Process Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Dephosphorylation Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Signaling Cell Division Circadian Rhythm Regulation Of Glycogen Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Dephosphorylation Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Carbohydrate Metabolic Process Swimming Behavior Kynurenic Acid Biosynthetic Process Peptidyl-histidine Dephosphorylation Regulation Of Signal Transduction Lipid Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Energy Derivation By Oxidation Of Organic Compounds Rhythmic Process Regulation Of Signaling Adherens Junction Organization Negative Regulation Of ATP Citrate Synthase Activity Sulfate Assimilation Cytokine Production Involved In Inflammatory Response Protection From Natural Killer Cell Mediated Cytotoxicity Response To Light Stimulus Response To External Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib
Tagcloud ?		adenovirus adjacent arresting believed catalyzing cck comparatively cycles discrepancies downregulating endometrial estrogen estrogens expressions mcf meanwhile proliferating prominent retarded subcutaneous sulfate sulfation sult1e1 tumorous universal upregulating xenograft	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		adenovirus adjacent arresting believed catalyzing cck comparatively cycles discrepancies downregulating estrogen estrogens expressions mcf meanwhile proliferating prominent retarded subcutaneous sulfate sulfation sult1e1 tumorous universal upregulating xenograft	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?		endometrial