HLA-DQA1 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		HLA-DQA1	UNC119
Gene Name		major histocompatibility complex, class II, DQ alpha 1	unc-119 homolog (C. elegans)
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding Lipid Binding
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of T Cell Differentiation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 23181788) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656) Chronic lymphocytic leukemia ( 21131588) Crohn's disease ( 23266558) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) Immune response to anthrax vaccine ( 22658931) Inflammatory bowel disease ( 18758464) Leishmaniasis (visceral) ( 23291585) Lymphoma ( 23349640) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nephropathy (idiopathic membranous) ( 21323541) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 21653640) Schizophrenia ( 23212062 19571809) Systemic lupus erythematosus ( 18204098 21408207) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 21297633 19122664 23511034) Vitiligo ( 20410501)
Protein-Protein Interactions		8 interactors: APLP1 CD74 CDK7 IKBKG LRIF1 SH3GL2 TLE1 UNC119	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		3117	9094
HPRD ID		06765	04927
Ensembl ID		ENSG00000196735	ENSG00000109103
Uniprot IDs		B7ZW51 L8E864 P01909 Q08AS3 Q30063 Q5Y7H0 Q8MH44	Q13432
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6	3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Signaling Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Clathrin-mediated Endocytosis Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Signaling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Protein Kinase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Kinase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transferase Activity Negative Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stimulus Activation Of MAPK Activity Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis RNA Metabolic Process Response To Norepinephrine Intracellular Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Localization Positive Regulation Of MAP Kinase Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Gene Expression Mitotic Cytokinetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
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