HLA-DQA1

Gene Name		major histocompatibility complex, class II, DQ alpha 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of T Cell Differentiation T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 23181788) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656) Chronic lymphocytic leukemia ( 21131588) Crohn's disease ( 23266558) Hepatocellular carcinoma ( 22807686) Hypothyroidism ( 22493691) Immune response to anthrax vaccine ( 22658931) Inflammatory bowel disease ( 18758464) Leishmaniasis (visceral) ( 23291585) Lymphoma ( 23349640) Multiple sclerosis (OCB status) ( 23472185) Nephropathy ( 21399633) Nephropathy (idiopathic membranous) ( 21323541) Prostate cancer ( 23535732) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 21653640) Schizophrenia ( 23212062 19571809) Systemic lupus erythematosus ( 18204098 21408207) Systemic sclerosis ( 21779181) Ulcerative colitis ( 23128233 21297633 19122664 23511034) Vitiligo ( 20410501)
Protein-protein Interactions		8 interactors: APLP1 CD74 CDK7 IKBKG LRIF1 SH3GL2 TLE1 UNC119
Entrez ID		3117
HPRD ID		06765
Ensembl ID		ENSG00000196735
Uniprot IDs		B7ZW51 L8E864 P01909 Q08AS3 Q30063 Q5Y7H0 Q8MH44
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 4GG6
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Signaling Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Clathrin-mediated Endocytosis Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Signaling Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Protein Kinase Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Kinase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Phosphorylation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transferase Activity Negative Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stimulus Activation Of MAPK Activity Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis RNA Metabolic Process Response To Norepinephrine Intracellular Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Localization Positive Regulation Of MAP Kinase Activity Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Gene Expression Mitotic Cytokinetic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?