MYL2 and USP6

Number of citations of the paper that reports this interaction (PubMedID 16555005)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MYL2	USP6
Description		myosin light chain 2	ubiquitin specific peptidase 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril	Cytoplasm Lysosome Endosome Golgi Apparatus Plasma Membrane Membrane Recycling Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Calmodulin Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction	Proteolysis Protein Deubiquitination Protein Modification Process Regulation Of Vesicle-mediated Transport Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Serum uric acid levels ( 32514006) Urate levels ( 31578528) White blood cell count ( 29403010)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529	18 interacting genes: ANKRD11 ANKRD44 APP ATXN7L3 CABP2 CALM2 CDC42 EXOSC8 JAK1 JUN MDFI MYL2 RAB33B RAC1 RIPPLY1 TFIP11 UBC ZNF76
Entrez ID		4633	9098
HPRD ID		01181	06827
Ensembl ID		ENSG00000111245	ENSG00000129204
Uniprot IDs		A0A590UJU8 G3V1V8 P10916 Q6IB42	P35125
PDB IDs		5TBY 8ACT 8G4L
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy	Anatomical Structure Morphogenesis Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process G Protein Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Neuron Projection Organization Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Postsynapse Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Macrophage Activation Intracellular Signaling Cassette Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Projection Development Regulation Of Postsynapse Organization Endocytosis Lipoprotein Particle Dendrite Development Positive Regulation Of Protein Import Microglial Cell Activation Regulation Of Nitric Oxide Metabolic Process Regulation Of MAPK Cascade Leukocyte Activation Involved In Inflammatory Response Supramolecular Fiber Organization Calcium Channel Regulator Activity Substantia Nigra Development Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Heart Process Wnt Signaling Pathway, Planar Cell Polarity Pathway GTP-dependent Protein Binding Heart Contraction Positive Regulation Of Stress Fiber Assembly Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis, Engulfment Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination GBD Domain Binding
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