MYL2 and GJB5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MYL2	GJB5
Gene Name		myosin, light chain 2, regulatory, cardiac, slow	gap junction protein, beta 5, 31.1kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band	Connexon Complex Integral Component Of Membrane
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding
	Biological Process	Regulation Of Striated Muscle Contraction Post-embryonic Development Muscle Filament Sliding Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Fiber Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Cell Communication Epidermis Development Spongiotrophoblast Differentiation Labyrinthine Layer Morphogenesis
Pathways		Striated Muscle Contraction	Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) HDL cholesterol ( 21909109)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		9 interactors: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PPP1R12C TRIM63 USP6	5 interactors: GSK3B MED1 MYL2 PCGF2 TRIM2
Entrez ID		4633	2709
HPRD ID		01181	06840
Ensembl ID		ENSG00000111245	ENSG00000189280
Uniprot IDs		P10916 Q6IB42	O95377
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy RRNA Pseudouridine Synthesis Ubiquitin-dependent Endocytosis ERBB2 Signaling Pathway Protein Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spongiotrophoblast Differentiation Cellular Protein Modification Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Viral Budding Proteasomal Protein Catabolic Process Muscle System Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Neuronal Ion Channel Clustering Nuclear Migration Negative Regulation Of Actin Filament Bundle Assembly	Organ Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Apoptotic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Regulation Of Cell Death Cardiac Ventricle Morphogenesis Muscle Structure Development Cardiac Ventricle Development Positive Regulation Of Nucleocytoplasmic Transport Thyroid Hormone Mediated Signaling Pathway Muscle Cell Fate Specification Fat Cell Differentiation Regulation Of Epithelial Cell Differentiation Cardiac Chamber Development Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Cardiac Muscle Tissue Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Cell Death Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Hypermethylation Of CpG Island Positive Regulation Of G0 To G1 Transition Enucleate Erythrocyte Development Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Anatomical Structure Formation Involved In Morphogenesis Heart Morphogenesis Striated Muscle Cell Differentiation Depyrimidination Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Organ Development Regulation Of Vitamin D Receptor Signaling Pathway Mammary Gland Branching Involved In Thelarche Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Hepatocyte Proliferation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Tagcloud ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage	5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology subpopulations tgc tpbpa trophoblast
Tagcloud (Difference) ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage	5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology subpopulations tgc tpbpa trophoblast
Tagcloud (Intersection) ?