MYL2 and NHP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MYL2	NHP2
Description		myosin light chain 2	NHP2 ribonucleoprotein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding U3 SnoRNA Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction	SnoRNA Guided RRNA Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Ribosome Biogenesis Telomerase RNA Localization To Cajal Body
Pathways		Striated Muscle Contraction	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM)	Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Hypertension ( 32709000) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Serum uric acid levels ( 32514006) Urate levels ( 31578528) White blood cell count ( 29403010)	Platelet count ( 29403010)
Interacting Genes		12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529	10 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOS1AP PRNP RSPH1 UBE2I UTP23
Entrez ID		4633	55651
HPRD ID		01181	07570
Ensembl ID		ENSG00000111245	ENSG00000145912
Uniprot IDs		A0A590UJU8 G3V1V8 P10916 Q6IB42	J3QSY4 Q9NX24
PDB IDs		5TBY 8ACT 8G4L	7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Transmembrane Transporter Binding Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Cytosol Neuromuscular Junction Development Regulation Of Membrane Repolarization Receptor Metabolic Process Regulation Of T Cell Receptor Signaling Pathway Muscle Cell Fate Specification Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Type 8 Metabotropic Glutamate Receptor Binding SUMO Conjugating Enzyme Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Component Assembly Signaling Adaptor Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Regulation Of Membrane Potential Phosphothreonine Residue Binding Negative Regulation Of Monoatomic Ion Transport Regulation Of Dendrite Development RING-like Zinc Finger Domain Binding Linear Polyubiquitin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Homooligomerization
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