MYL2

Name	myosin light chain 2
Structure
Interactors	12 interactors: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways	Striated Muscle Contraction
Diseases	Hypertrophic cardiomyopathy (HCM)
GWAS	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Alcohol consumption (max-drinks) ( 29460428 ) Body mass index ( 24861553 ) Coffee consumption ( 29367735 ) Coronary heart disease ( 23364394 ) Drinking behavior ( 23364009 ) Gamma glutamyl transpeptidase ( 21909109 ) Glycemic traits ( 23575436 ) Gout ( 25646370 ) HDL cholesterol ( 21909109 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Metabolic syndrome ( 25705158 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Neutrophil count ( 29403010 ) Serum uric acid levels ( 32514006 ) Urate levels ( 31578528 ) White blood cell count ( 29403010 )
Entrez ID	4633
HPRD ID	01181
Ensembl ID	ENSG00000111245
Uniprot IDs	A0A590UJU8 G3V1V8 P10916 Q6IB42
PDB IDs	5TBY 8ACT 8G4L
GO Terms Enriched among Interactors ?	Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy