MYL2 and CDC42BPA

Number of citations: 54 (PubMedID 9418861)
Data Source: HPRD (in vitro)

		MYL2	CDC42BPA
Name		myosin light chain 2	CDC42 binding protein kinase alpha
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction	Protein Phosphorylation Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		Striated Muscle Contraction	CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Diseases		Hypertrophic cardiomyopathy (HCM)	None
GWAS		Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Alcohol consumption (max-drinks) ( 29460428 ) Body mass index ( 24861553 ) Coffee consumption ( 29367735 ) Coronary heart disease ( 23364394 ) Drinking behavior ( 23364009 ) Gamma glutamyl transpeptidase ( 21909109 ) Glycemic traits ( 23575436 ) Gout ( 25646370 ) HDL cholesterol ( 21909109 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Metabolic syndrome ( 25705158 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Neutrophil count ( 29403010 ) Serum uric acid levels ( 32514006 ) Urate levels ( 31578528 ) White blood cell count ( 29403010 )	Blond vs. brown/black hair color ( 30531825 ) Blood urea nitrogen levels ( 31152163 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Diastolic blood pressure ( 28135244 ) Low density lipoprotein cholesterol levels ( 33339817 ) Macular thickness ( 30535121 ) Mercury levels ( 26025379 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Optic cup area ( 25631615 31798171 ) Optic disc area ( 25631615 31798171 28073927 ) Optic disc size ( 31809533 ) SAPHO syndrome ( 33816493 ) Smoking initiation ( 33082346 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 34021172 ) White blood cell count ( 32888494 )
Interacting Genes		12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529	10 interacting genes: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1 USP7
Entrez ID		4633	8476
HPRD ID		01181	04562
Ensembl ID		ENSG00000111245	ENSG00000143776
Uniprot IDs		A0A590UJU8 G3V1V8 P10916 Q6IB42	A0A0A0MRJ0 A0A0A0MRJ1 Q5VT25
PDB IDs		5TBY 8ACT 8G4L	Not available
GO Terms Enriched among Interactors		Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy	Actin Filament-based Process Actin Cytoskeleton Organization Supramolecular Fiber Organization Myosin Heavy Chain Binding Actomyosin Structure Organization Heart Contraction Cytoskeleton Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Organelle Organization Cytoskeleton Organization Myofibril Assembly Heart Process Structural Constituent Of Muscle Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Establishment Of Organelle Localization Regulation Of Cell Projection Organization Myosin Complex Myofibril Regulation Of Intracellular Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Muscle Cell Fate Specification Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Late Endosome To Lysosome Transport Actin Filament Bundle Organization P53 Binding Cellular Component Assembly Protein Serine Kinase Activity Protein Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Component Organization GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Negative Regulation Of Protein Autoubiquitination Stress Fiber Phosphorylation Protein Modification Process Regulation Of Cell Growth Regulation Of Stress Fiber Assembly Protein Serine/threonine Kinase Activity Developmental Process Endothelin Receptor Signaling Pathway Involved In Heart Process Establishment Of Vesicle Localization Symbiont-mediated Disruption Of Host Cell PML Body Organelle Localization