KALRN and SUMO3

Number of citations of the paper that reports this interaction (PMID 16620772)
10

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KALRN	SUMO3
Gene Name		kalirin, RhoGEF kinase	small ubiquitin-like modifier 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Cytoskeleton Extracellular Vesicular Exosome	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding SUMO Transferase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Nervous System Development Axon Guidance Vesicle-mediated Transport Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling EPHB-mediated forward signaling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events	SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419)
Protein-Protein Interactions		15 interactors: ATXN7 CACNA1A CDC5L COIL DISC1 DTNBP1 EPHB2 FASLG GFI1B LNX1 NDEL1 PAM RAC1 SUMO2 SUMO3	53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM
Entrez ID		8997	6612
HPRD ID		06859	03754
Ensembl ID		ENSG00000160145	ENSG00000184900
Uniprot IDs		J3QSW6 O60229	B4DUW4 P55854
PDB IDs			1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Central Nervous System Neuron Differentiation Central Nervous System Neuron Development Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cell Projection Organization Central Nervous System Neuron Axonogenesis Neuron Development Cellular Chloride Ion Homeostasis Central Nervous System Development Generation Of Neurons Chloride Ion Homeostasis Dendrite Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Cerebral Cortex Cell Migration Neurogenesis Telencephalon Development Positive Regulation Of Proteolysis Neuron Differentiation Telencephalon Cell Migration Forebrain Cell Migration Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Regulation Of Cellular Component Organization Brain Development Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Head Development Dendrite Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Sumoylation Regulation Of Cell Development Positive Regulation Of Cellular Protein Catabolic Process Endomembrane System Organization Regulation Of Axonogenesis Cerebral Cortex Development Forebrain Development Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Cell Morphogenesis System Development Nervous System Development Positive Regulation Of Cell Development Anatomical Structure Morphogenesis	Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Difference) ?		actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 l576 melanomas mined ngs nras pik3r4 ppp6c prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Intersection) ?